(6E)-2-(5-benzyloxy-4-methylpentyl)-3-dimethyl-t-butylsilyloxy-6-2-dimethyl-t-butylsilyloxyethylidene-2-methyloxepane

Base Information

Chemical Name:(6E)-2-(5-benzyloxy-4-methylpentyl)-3-dimethyl-t-butylsilyloxy-6-2-dimethyl-t-butylsilyloxyethylidene-2-methyloxepane
CAS No.:100582-56-7
Molecular Formula:C₃₄H₆₂O₄Si₂
Molecular Weight:591.035
Hs Code.:

Synonyms:(6E)-2-(5-benzyloxy-4-methylpentyl)-3-dimethyl-t-butylsilyloxy-6-2-dimethyl-t-butylsilyloxyethylidene-2-methyloxepane

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Chemical Property of (6E)-2-(5-benzyloxy-4-methylpentyl)-3-dimethyl-t-butylsilyloxy-6-2-dimethyl-t-butylsilyloxyethylidene-2-methyloxepane

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Technology Process of (6E)-2-(5-benzyloxy-4-methylpentyl)-3-dimethyl-t-butylsilyloxy-6-2-dimethyl-t-butylsilyloxyethylidene-2-methyloxepane

There total 13 articles about (6E)-2-(5-benzyloxy-4-methylpentyl)-3-dimethyl-t-butylsilyloxy-6-2-dimethyl-t-butylsilyloxyethylidene-2-methyloxepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 100582-54-5
(6E)-2-(5-benzyloxy-4-methylpentyl)-6-(2-hydroxyethylidene)-2-methyl-oxepan-3-ol

: 100582-56-7
(6E)-2-(5-benzyloxy-4-methylpentyl)-3-dimethyl-t-butylsilyloxy-6-2-dimethyl-t-butylsilyloxyethylidene-2-methyloxepane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -20 ℃; for 0.333333h;

Reference yield:

: 2468-55-5
5-iodopent-1-yne

: 100582-56-7
(6E)-2-(5-benzyloxy-4-methylpentyl)-3-dimethyl-t-butylsilyloxy-6-2-dimethyl-t-butylsilyloxyethylidene-2-methyloxepane

Guidance literature:: Multi-step reaction with 13 steps

1: 1.) LDA, 2.) hexamethylphosphoramide / 1.) THF, -78 deg C, 1 h; 2.) THF, -78 deg C to room temperature, 15 h

2: 94 percent / lithium aluminium hydride / diethyl ether / 1.5 h / 0 °C

3: 85 percent / sodium hydride / dimethylformamide / 12 h / 0 - 20 °C

4: zirconiumbis(cyclopentadienyl) dichloride, n-Bu-Li

5: triethylamine / CH₂Cl₂ / 1 h / -5 °C

6: 15.84 g / sodium iodide / acetone / 15 h / Ambient temperature

7: 1.) THF, -78 deg C to room temp., 15 h; 2.) toluene, 3 h, reflux

8: 97 percent / di-isobutylaluminum hydride / toluene / 1 h / -78 - -30 °C

9: 99 percent / triethylamine / tetrahydrofuran / 1 h / -20 - 20 °C

10: 94 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 0 °C

11: 97 percent / anhydrous potassium carbonate / methanol / 1 h / 0 °C

12: 79 percent / stannic chloride / tetrahydrofuran / 0.58 h / Ambient temperature

13: 95 percent / 2,6-dimethylpyridine / CH₂Cl₂ / 0.33 h / -20 °C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; n-butyllithium; zirconocene dichloride; diisobutylaluminum hydride; tin(IV) chloride; sodium hydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 100582-49-8
2-methylhept-6-yn-1-ol

: 100582-56-7
(6E)-2-(5-benzyloxy-4-methylpentyl)-3-dimethyl-t-butylsilyloxy-6-2-dimethyl-t-butylsilyloxyethylidene-2-methyloxepane

Guidance literature:: Multi-step reaction with 11 steps

1: 85 percent / sodium hydride / dimethylformamide / 12 h / 0 - 20 °C

2: zirconiumbis(cyclopentadienyl) dichloride, n-Bu-Li

3: triethylamine / CH₂Cl₂ / 1 h / -5 °C

4: 15.84 g / sodium iodide / acetone / 15 h / Ambient temperature

5: 1.) THF, -78 deg C to room temp., 15 h; 2.) toluene, 3 h, reflux

6: 97 percent / di-isobutylaluminum hydride / toluene / 1 h / -78 - -30 °C

7: 99 percent / triethylamine / tetrahydrofuran / 1 h / -20 - 20 °C

8: 94 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 0 °C

9: 97 percent / anhydrous potassium carbonate / methanol / 1 h / 0 °C

10: 79 percent / stannic chloride / tetrahydrofuran / 0.58 h / Ambient temperature

11: 95 percent / 2,6-dimethylpyridine / CH₂Cl₂ / 0.33 h / -20 °C

With 2,6-dimethylpyridine; n-butyllithium; zirconocene dichloride; diisobutylaluminum hydride; tin(IV) chloride; sodium hydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;