<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-dimethoxyphosphonoethan-1-one

Base Information

Chemical Name:<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-dimethoxyphosphonoethan-1-one
CAS No.:110672-03-2
Molecular Formula:C₁₉H₂₉O₆P
Molecular Weight:384.409
Hs Code.:

Synonyms:<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-dimethoxyphosphonoethan-1-one

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Chemical Property of <(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-dimethoxyphosphonoethan-1-one

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Technology Process of <(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-dimethoxyphosphonoethan-1-one

There total 14 articles about <(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-dimethoxyphosphonoethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126394-13-6
methyl <(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran>-2-carboxylate

: 756-79-6
dimethyl methane phosphonate

: 110672-03-2
<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-dimethoxyphosphonoethan-1-one

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -93 ℃; Yield given;
DOI:10.1016/S0040-4039(00)95485-6

Reference yield:

: 126394-10-3
(2S,3E,6S)-2-benzyloxymethoxy-6,7-diisopropylidenedioxyhept-4-en-3-one

: 110672-03-2
<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-dimethoxyphosphonoethan-1-one

Guidance literature:: Multi-step reaction with 9 steps

1: 98 percent / hydrogen / 10percent Pd/C / ethyl acetate / 1 h

2: 100 percent / tetrahydrofuran / 2 h / -93 °C

3: 100 percent / NaH / dimethylformamide / Ambient temperature

4: 85 percent / 4N HCl / tetrahydrofuran / 2 h / 50 °C

5: 59 percent / pyridine / 8.5 h / Ambient temperature

6: 68 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 1.75 h / Ambient temperature

7: CrO₃, H₂SO₄ / acetone / 1 h / 0 °C

8: diethyl ether

9: 1) n-BuLi / 1) THF, -93 deg C, 30 min, 2) THF, -93 to 20 deg C

With pyridine; chromium(VI) oxide; hydrogenchloride; n-butyllithium; sulfuric acid; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.37.1705

Reference yield:

: 113643-40-6
<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran>-2-methanol

: 110672-03-2
<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-dimethoxyphosphonoethan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: CrO₃, H₂SO₄ / acetone / 1 h / 0 °C

2: diethyl ether

3: 1) n-BuLi / 1) THF, -93 deg C, 30 min, 2) THF, -93 to 20 deg C

With chromium(VI) oxide; n-butyllithium; sulfuric acid; In diethyl ether; acetone;
DOI:10.1248/cpb.37.1705