2-amino-7-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-4(3H)-selone

Base Information

• Chemical Name: 2-amino-7-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-4(3H)-selone
• CAS No.: 170468-43-6
• Molecular Formula: C₂₅H₂₁FN₄O₅Se
• Molecular Weight: 555.424
• Mol file: 170468-43-6.mol

Synonyms:2-amino-7-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-4(3H)-selone

Chemical Property of 2-amino-7-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-4(3H)-selone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-7-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-4(3H)-selone

There total 3 articles about 2-amino-7-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-4(3H)-selone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-amino-4-chloro-7-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine (170468-33-4) → 2-amino-7-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-4(3H)-selone (170468-43-6)

Guidance literature:

With selenourea; In ethanol; for 3h; Heating;

DOI:10.1021/jm00020a009

Reference yield:

2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide (97614-44-3) → 2-amino-7-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-4(3H)-selone (170468-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) CH₃CN, RT, 1 H, 2.) CH₃CN, RT, 24 h

2: 75 percent / selenourea / ethanol / 3 h / Heating

With selenourea; sodium hydride; In ethanol;

DOI:10.1021/jm00020a009

Reference yield:

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (84955-31-7) → 2-amino-7-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-4(3H)-selone (170468-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) CH₃CN, RT, 1 H, 2.) CH₃CN, RT, 24 h

2: 75 percent / selenourea / ethanol / 3 h / Heating

With selenourea; sodium hydride; In ethanol;

DOI:10.1021/jm00020a009

upstream raw materials:

2-amino-4-chloro-7-(2-deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine

2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide

4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine