(3S)-3-<(tert-Butyldimethylsilyl)oxy>pentanedioic acid 1-<(S)-mandelic acid> ester

Base Information

• Chemical Name: (3S)-3-<(tert-Butyldimethylsilyl)oxy>pentanedioic acid 1-<(S)-mandelic acid> ester
• CAS No.: 160204-81-9
• Molecular Formula: C₁₉H₂₈O₇Si
• Molecular Weight: 396.513
• Mol file: 160204-81-9.mol

Synonyms:(3S)-3-<(tert-Butyldimethylsilyl)oxy>pentanedioic acid 1-<(S)-mandelic acid> ester

Chemical Property of (3S)-3-<(tert-Butyldimethylsilyl)oxy>pentanedioic acid 1-<(S)-mandelic acid> ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S)-3-<(tert-Butyldimethylsilyl)oxy>pentanedioic acid 1-<(S)-mandelic acid> ester

There total 3 articles about (3S)-3-<(tert-Butyldimethylsilyl)oxy>pentanedioic acid 1-<(S)-mandelic acid> ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-<(tert-Butyldimethylsilyl)oxy>pentanedioic acid 1- ester → (3S)-3-<(tert-Butyldimethylsilyl)oxy>pentanedioic acid 1-<(S)-mandelic acid> ester (160204-81-9)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethyl acetate; Ambient temperature;

DOI:10.1021/jo00104a049

Reference yield:

3-(tert-butyldimethylsilyloxy)glutaric anhydride (91424-40-7) → (3S)-3-<(tert-Butyldimethylsilyl)oxy>pentanedioic acid 1-<(S)-mandelic acid> ester (160204-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: BuLi / tetrahydrofuran; hexane

2: H₂ / Pd(OH)2/C / ethyl acetate / Ambient temperature

With n-butyllithium; hydrogen; palladium dihydroxide; In tetrahydrofuran; hexane; ethyl acetate;

DOI:10.1021/jo00104a049

Reference yield:

(S)-benzyl 2-hydroxy-2-phenylacetate (62173-99-3) → (3S)-3-<(tert-Butyldimethylsilyl)oxy>pentanedioic acid 1-<(S)-mandelic acid> ester (160204-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: BuLi / tetrahydrofuran; hexane

2: H₂ / Pd(OH)2/C / ethyl acetate / Ambient temperature

With n-butyllithium; hydrogen; palladium dihydroxide; In tetrahydrofuran; hexane; ethyl acetate;

DOI:10.1021/jo00104a049

upstream raw materials:

3-(tert-butyldimethylsilyloxy)glutaric anhydride

(S)-benzyl 2-hydroxy-2-phenylacetate

Refernces