methyl (3R,6S,8R)-8-{4'-[4-(tert-butoxycarbonyl)piperazin-1-yl]biphenyl-4-yl}-6-(2-fluoro-2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yne-3-carboxylate

Base Information

Chemical Name:methyl (3R,6S,8R)-8-{4'-[4-(tert-butoxycarbonyl)piperazin-1-yl]biphenyl-4-yl}-6-(2-fluoro-2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yne-3-carboxylate
CAS No.:1064623-19-3
Molecular Formula:C₃₆H₄₄F₄N₄O₅S
Molecular Weight:720.829
Hs Code.:

methyl (3R,6S,8R)-8-{4'-[4-(tert-butoxycarbonyl)piperazin-1-yl]biphenyl-4-yl}-6-(2-fluoro-2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yne-3-carboxylate

Synonyms:methyl (3R,6S,8R)-8-{4'-[4-(tert-butoxycarbonyl)piperazin-1-yl]biphenyl-4-yl}-6-(2-fluoro-2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yne-3-carboxylate

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Chemical Property of methyl (3R,6S,8R)-8-{4'-[4-(tert-butoxycarbonyl)piperazin-1-yl]biphenyl-4-yl}-6-(2-fluoro-2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yne-3-carboxylate

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Technology Process of methyl (3R,6S,8R)-8-{4'-[4-(tert-butoxycarbonyl)piperazin-1-yl]biphenyl-4-yl}-6-(2-fluoro-2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yne-3-carboxylate

There total 1 articles about methyl (3R,6S,8R)-8-{4'-[4-(tert-butoxycarbonyl)piperazin-1-yl]biphenyl-4-yl}-6-(2-fluoro-2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yne-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1064623-08-0
methyl (3R,6S₈R)-8-(4-bromophenyl)-6-(2-fluoro-2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yne-3-carboxylate

: 457613-78-4
4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylboronic acid

: 1064623-19-3
methyl (3R,6S,8R)-8-{4'-[4-(tert-butoxycarbonyl)piperazin-1-yl]biphenyl-4-yl}-6-(2-fluoro-2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yne-3-carboxylate

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; at 90 ℃;

Reference yield:

: 1064623-19-3
methyl (3R,6S,8R)-8-{4'-[4-(tert-butoxycarbonyl)piperazin-1-yl]biphenyl-4-yl}-6-(2-fluoro-2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yne-3-carboxylate

: 1064623-20-6
(3R,6S,8R)-8-{4'-[4-(tert-butoxycarbonyl)piperazin-1-yl]biphenyl-4-yl}-6-(2-fluoro-2-methylpropyl)-8-(trifluoromethyl)-5-oxo-1-thia-4,7-diazacycloundec-9-yne-3-carboxylic acid

Guidance literature:: methyl (3R,6S,8R)-8-{4'-[4-(tert-butoxycarbonyl)piperazin-1-yl]biphenyl-4-yl}-6-(2-fluoro-2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yne-3-carboxylate; With lithium hydroxide; water; In methanol; 1,2-dimethoxyethane; at 20 ℃; for 2.5h;

With hydrogenchloride; In methanol; 1,2-dimethoxyethane; water;