7,8-dihydroxy-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Base Information

Chemical Name:7,8-dihydroxy-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
CAS No.:136247-28-4
Molecular Formula:C₁₆H₁₈N₂O₂*ClH
Molecular Weight:306.792
Hs Code.:

Synonyms:7,8-dihydroxy-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7,8-dihydroxy-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Chemical Property:

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Technology Process of 7,8-dihydroxy-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

There total 5 articles about 7,8-dihydroxy-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 136247-27-3
1-(4-Nitro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrochloride

: 136247-28-4
7,8-dihydroxy-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 48h; under 2327.2 Torr;
DOI:10.1021/jm00115a012

Reference yield:

: 6388-74-5,38201-14-8,71884-55-4
p-Nitrophenyloxirane

: 136247-28-4
7,8-dihydroxy-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 35 percent / tetrahydrofuran / Heating

2: polyphosphoric acid (PPA) / 1 h / 100 °C

3: 81 percent / 12 N aq. HCl / 24 h / Heating

4: 60 percent / H₂ / 10percent Pd/C / ethanol / 48 h / 2327.2 Torr

With hydrogenchloride; PPA; Polyphosphoric acid (PPA); hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00115a012

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 136247-28-4
7,8-dihydroxy-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 35 percent / tetrahydrofuran / Heating

2: polyphosphoric acid (PPA) / 1 h / 100 °C

3: 81 percent / 12 N aq. HCl / 24 h / Heating

4: 60 percent / H₂ / 10percent Pd/C / ethanol / 48 h / 2327.2 Torr

With hydrogenchloride; PPA; Polyphosphoric acid (PPA); hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00115a012