2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid tert-butyl ester

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Chemical Name:2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid tert-butyl ester
CAS No.:195310-62-4
Molecular Formula:C₃₅H₃₄F₃N₃O₆
Molecular Weight:649.667
Hs Code.:

2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-<i>N</i>-(3-trifluoromethyl-benzyl)-malonamic acid <i>tert</i>-butyl ester

Synonyms:2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid tert-butyl ester

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Chemical Property of 2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid tert-butyl ester

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Technology Process of 2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid tert-butyl ester

There total 7 articles about 2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 195310-61-3
2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-malonic acid tert-butyl ester 2,2,2-trichloro-ethyl ester

: 2740-83-2
3-(TRIFLUOROMETHYL)BENZYLAMINE

: 195310-62-4
2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; Heating;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: (3-phenyl-allylideneamino)-acetic acid tert-butyl ester

: 195310-62-4
2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 5.5 g / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

2.2: 56 percent / tetrahydrofuran

3.1: 82 percent / tetrahydrofuran / Heating

With lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1.1: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 195310-62-4
2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: desiccating agent / CH₂Cl₂ / 20 °C

2.1: 5.5 g / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

3.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

3.2: 56 percent / tetrahydrofuran

4.1: 82 percent / tetrahydrofuran / Heating

With desiccating agent; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 2.1: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031