4-Phenyl-2-mercapto-5,6,7,8-tetrahydrobenzo<4,5>thieno<2,3-d>pyrimidine

Base Information

• Chemical Name: 4-Phenyl-2-mercapto-5,6,7,8-tetrahydrobenzo<4,5>thieno<2,3-d>pyrimidine
• CAS No.: 128352-80-7
• Molecular Formula: C₁₆H₁₄N₂S₂
• Molecular Weight: 298.433

Synonyms:4-Phenyl-2-mercapto-5,6,7,8-tetrahydrobenzo<4,5>thieno<2,3-d>pyrimidine

Chemical Property of 4-Phenyl-2-mercapto-5,6,7,8-tetrahydrobenzo<4,5>thieno<2,3-d>pyrimidine

Chemical Property:

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Technology Process of 4-Phenyl-2-mercapto-5,6,7,8-tetrahydrobenzo<4,5>thieno<2,3-d>pyrimidine

There total 3 articles about 4-Phenyl-2-mercapto-5,6,7,8-tetrahydrobenzo<4,5>thieno<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-Amino-4-phenyl-2-thioxo-2,3,5,6,7,8-hexahydrobenzo<4,5>thieno<2,3-d>pyrimidine (114752-07-7) → 4-Phenyl-2-mercapto-5,6,7,8-tetrahydrobenzo<4,5>thieno<2,3-d>pyrimidine (128352-80-7)

Guidance literature:

With sodium nitrite; In acetic acid; for 20h; Ambient temperature;

DOI:10.1002/jhet.5570270229

Reference yield:

2-amino-3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophene (4651-72-3) → 4-Phenyl-2-mercapto-5,6,7,8-tetrahydrobenzo<4,5>thieno<2,3-d>pyrimidine (128352-80-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / calcium carbonate / CHCl₃; H₂O / 4 h / 10 - 15 °C

2: 90 percent / aqueous hydrazine hydrate (80 percent) / dioxane / 0.5 h / 10 °C

3: 71 percent / sodium nitrite / aq. acetic acid / 20 h / Ambient temperature

With hydrazine hydrate; calcium carbonate; sodium nitrite; In 1,4-dioxane; chloroform; water; acetic acid;

DOI:10.1002/jhet.5570270229

Reference yield:

3-Benzoyl-2-isothiocyanato-4,5,6,7-tetrahydrobenzothiophene (119934-31-5) → 4-Phenyl-2-mercapto-5,6,7,8-tetrahydrobenzo<4,5>thieno<2,3-d>pyrimidine (128352-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / aqueous hydrazine hydrate (80 percent) / dioxane / 0.5 h / 10 °C

2: 71 percent / sodium nitrite / aq. acetic acid / 20 h / Ambient temperature

With hydrazine hydrate; sodium nitrite; In 1,4-dioxane; acetic acid;

DOI:10.1002/jhet.5570270229

upstream raw materials:

3-Amino-4-phenyl-2-thioxo-2,3,5,6,7,8-hexahydrobenzo<4,5>thieno<2,3-d>pyrimidine

2-amino-3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophene

3-Benzoyl-2-isothiocyanato-4,5,6,7-tetrahydrobenzothiophene

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