4-chloro-2-(4-methylphenyl)-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidine 7-oxide

Base Information

Chemical Name:4-chloro-2-(4-methylphenyl)-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidine 7-oxide
CAS No.:1649436-07-6
Molecular Formula:C₁₉H₁₅ClN₂OS
Molecular Weight:354.86
Hs Code.:

Synonyms:4-chloro-2-(4-methylphenyl)-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidine 7-oxide

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Chemical Property of 4-chloro-2-(4-methylphenyl)-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidine 7-oxide

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Technology Process of 4-chloro-2-(4-methylphenyl)-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidine 7-oxide

There total 3 articles about 4-chloro-2-(4-methylphenyl)-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidine 7-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1649435-71-1
4-chloro-2-(4-methylphenyl)-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidine

: 1649436-07-6
4-chloro-2-(4-methylphenyl)-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidine 7-oxide

Guidance literature:: With formic acid; dihydrogen peroxide; In dichloromethane; water; at 20 ℃; for 9h;
DOI:10.1002/jhet.1741

Reference yield:

: 88267-23-6
5-Oxo-2,3,4,5-tetrahydro<1>benzothiepin-4-carbonitrile

: 1649436-07-6
4-chloro-2-(4-methylphenyl)-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidine 7-oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / 40 h / 150 °C / 34503.5 Torr

2.1: trichlorophosphate / 1 h / Cooling with ice

2.2: 0.5 h / Reflux

3.1: dihydrogen peroxide; formic acid / dichloromethane; water / 9 h / 20 °C

With formic acid; ammonia; dihydrogen peroxide; trichlorophosphate; In dichloromethane; water;
DOI:10.1002/jhet.1741

Reference yield:

: 1649435-39-1
5-amino-2,3-dihydro-1-benzothiepin-4-carbonitrile

: 1649436-07-6
4-chloro-2-(4-methylphenyl)-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidine 7-oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 1 h / Cooling with ice

1.2: 0.5 h / Reflux

2.1: dihydrogen peroxide; formic acid / dichloromethane; water / 9 h / 20 °C

With formic acid; dihydrogen peroxide; trichlorophosphate; In dichloromethane; water;
DOI:10.1002/jhet.1741