(E)-5-[(3aR,6aS)-1,3-Dibenzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-(6E)-ylidene]-pent-3-enoic acid

Base Information

Chemical Name:(E)-5-[(3aR,6aS)-1,3-Dibenzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-(6E)-ylidene]-pent-3-enoic acid
CAS No.:153991-84-5
Molecular Formula:C₂₄H₂₄N₂O₃S
Molecular Weight:420.532
Hs Code.:

Synonyms:(E)-5-[(3aR,6aS)-1,3-Dibenzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-(6E)-ylidene]-pent-3-enoic acid

Suppliers and Price of (E)-5-[(3aR,6aS)-1,3-Dibenzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-(6E)-ylidene]-pent-3-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-5-[(3aR,6aS)-1,3-Dibenzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-(6E)-ylidene]-pent-3-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-5-[(3aR,6aS)-1,3-Dibenzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-(6E)-ylidene]-pent-3-enoic acid

There total 12 articles about (E)-5-[(3aR,6aS)-1,3-Dibenzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-(6E)-ylidene]-pent-3-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 367276-82-2
(3aS,4R,6aR)-1,3-dibenzyl-4-[(1E,3E)-4-methoxycarbonyl-1,3-butanedienyl]-1H-tetrahydrothieno[3,4-d]imidazol-2(3H)-one

: 153991-84-5
(E)-5-[(3aR,6aS)-1,3-Dibenzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-(6E)-ylidene]-pent-3-enoic acid

Guidance literature:: With sodium hydroxide; In methanol; at 0 ℃; for 15h;
DOI:10.1021/jo015730j

Reference yield:

: 154097-01-5
(3aS,4S,6aR)-1,3-dibenzyl-2-oxohexahydro-1H-thieno[3,4-d]imidazole-4-carbaldehyde

: 153991-84-5
(E)-5-[(3aR,6aS)-1,3-Dibenzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-(6E)-ylidene]-pent-3-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / Ba(OH)2*0.8H₂O / dioxane; H₂O / 2.5 h / 70 °C

2.1: aq. KOH; n-Bu₄NBr / methanol / 8 h / 20 °C

2.2: aq. HCl / CH₂Cl₂ / 5 - 10 °C

With barium dihydroxide; potassium hydroxide; tetrabutylammomium bromide; In 1,4-dioxane; methanol; water; 1.1: Horner-Emmons reaction;
DOI:10.1002/adsc.200404311

Reference yield:

: 28092-62-8
(3aS,6aR)-1,3-dibenzyltetrahydro-1H-furo[3,4-d]imidazole-2,4-dione

: 153991-84-5
(E)-5-[(3aR,6aS)-1,3-Dibenzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-(6E)-ylidene]-pent-3-enoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 80 percent / EtOC(S)SK / N,N-dimethyl-acetamide / 7 h / 125 °C

2.1: magnesium / dibutyl ether; toluene / 1 h / 45 °C

2.2: CH₂Cl₂; dibutyl ether / 3 h / 15 °C

2.3: 70 percent / aq. HCl / toluene; dibutyl ether / 3 h / Heating

3.1: 90 percent / Ba(OH)2*0.8H₂O / dioxane; H₂O / 2.5 h / 70 °C

4.1: aq. KOH; n-Bu₄NBr / methanol / 8 h / 20 °C

4.2: aq. HCl / CH₂Cl₂ / 5 - 10 °C

With barium dihydroxide; potassium hydroxide; tetrabutylammomium bromide; potassium ethyl xanthogenate; magnesium; In 1,4-dioxane; methanol; dibutyl ether; N,N-dimethyl acetamide; water; toluene; 2.1: Grignard reaction / 3.1: Horner-Emmons reaction;
DOI:10.1002/adsc.200404311