(2R/S,3R,5R,PR/S)-2-cyanoethoxy(diisopropylamino)-phosphinoxy-3-(4,4'-dimethoxytrityloxymethyl)-5-(uracil-1-yl)-1,4-dioxane

Base Information

Chemical Name:(2R/S,3R,5R,PR/S)-2-cyanoethoxy(diisopropylamino)-phosphinoxy-3-(4,4'-dimethoxytrityloxymethyl)-5-(uracil-1-yl)-1,4-dioxane
CAS No.:1146500-24-4
Molecular Formula:C₃₉H₄₇N₄O₉P
Molecular Weight:746.797
Hs Code.:

Synonyms:(2R/S,3R,5R,PR/S)-2-cyanoethoxy(diisopropylamino)-phosphinoxy-3-(4,4'-dimethoxytrityloxymethyl)-5-(uracil-1-yl)-1,4-dioxane

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Chemical Property of (2R/S,3R,5R,PR/S)-2-cyanoethoxy(diisopropylamino)-phosphinoxy-3-(4,4'-dimethoxytrityloxymethyl)-5-(uracil-1-yl)-1,4-dioxane

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Technology Process of (2R/S,3R,5R,PR/S)-2-cyanoethoxy(diisopropylamino)-phosphinoxy-3-(4,4'-dimethoxytrityloxymethyl)-5-(uracil-1-yl)-1,4-dioxane

There total 1 articles about (2R/S,3R,5R,PR/S)-2-cyanoethoxy(diisopropylamino)-phosphinoxy-3-(4,4'-dimethoxytrityloxymethyl)-5-(uracil-1-yl)-1,4-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1146500-21-1
(2RS,3R,5R)-3-(4,4'-dimethoxytrityloxymethyl)-2-hydroxy-5-(uracil-1-yl)-1,4-dioxane

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1146500-24-4
(2R/S,3R,5R,PR/S)-2-cyanoethoxy(diisopropylamino)-phosphinoxy-3-(4,4'-dimethoxytrityloxymethyl)-5-(uracil-1-yl)-1,4-dioxane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.41667h; Inert atmosphere;
DOI:10.1021/jo300222q

Reference yield:

: 288-94-8
1H-tetrazole

: 1146500-24-4
(2R/S,3R,5R,PR/S)-2-cyanoethoxy(diisopropylamino)-phosphinoxy-3-(4,4'-dimethoxytrityloxymethyl)-5-(uracil-1-yl)-1,4-dioxane

: C₃₄H₃₄N₇O₉P

Guidance literature:: In acetonitrile; for 1h; Inert atmosphere;
DOI:10.1021/jo300222q

Reference yield:

: 1146500-24-4
(2R/S,3R,5R,PR/S)-2-cyanoethoxy(diisopropylamino)-phosphinoxy-3-(4,4'-dimethoxytrityloxymethyl)-5-(uracil-1-yl)-1,4-dioxane

: C₃₆H₃₇N₄O₁₀P

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 1 h / Inert atmosphere

2: acetonitrile / Inert atmosphere

In acetonitrile;
DOI:10.1021/jo300222q