1-[3-(4-bromobenzo[b]thiophene-3-yl)propyl]-4-(2-methoxyphenyl)piperazine

Base Information

Chemical Name:1-[3-(4-bromobenzo[b]thiophene-3-yl)propyl]-4-(2-methoxyphenyl)piperazine
CAS No.:522648-82-4
Molecular Formula:C₂₂H₂₅BrN₂OS
Molecular Weight:445.423
Hs Code.:

Synonyms:1-[3-(4-bromobenzo[b]thiophene-3-yl)propyl]-4-(2-methoxyphenyl)piperazine

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Chemical Property of 1-[3-(4-bromobenzo[b]thiophene-3-yl)propyl]-4-(2-methoxyphenyl)piperazine

Chemical Property:

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Technology Process of 1-[3-(4-bromobenzo[b]thiophene-3-yl)propyl]-4-(2-methoxyphenyl)piperazine

There total 4 articles about 1-[3-(4-bromobenzo[b]thiophene-3-yl)propyl]-4-(2-methoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 522648-69-7
4-bromo-3-(3-chloropropyl)benzo[b]thiophene

: 522648-82-4
1-[3-(4-bromobenzo[b]thiophene-3-yl)propyl]-4-(2-methoxyphenyl)piperazine

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; at 80 ℃; for 18h;
DOI:10.1002/jhet.5570390611

Reference yield:

: 79386-90-6
1,5-Dichloro-2-pentanone

: 522648-82-4
1-[3-(4-bromobenzo[b]thiophene-3-yl)propyl]-4-(2-methoxyphenyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethylformamide / 1 h / 20 °C

2: 1.85 g / polyphosphoric acid / chlorobenzene / 20 h / 150 °C

3: 65 percent / potassium carbonate; sodium iodide / acetonitrile / 18 h / 80 °C

With PPA; potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; chlorobenzene; acetonitrile;
DOI:10.1002/jhet.5570390611

Reference yield:

: 6320-01-0
3-Bromothiophenol

: 522648-82-4
1-[3-(4-bromobenzo[b]thiophene-3-yl)propyl]-4-(2-methoxyphenyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethylformamide / 1 h / 20 °C

2: 1.85 g / polyphosphoric acid / chlorobenzene / 20 h / 150 °C

3: 65 percent / potassium carbonate; sodium iodide / acetonitrile / 18 h / 80 °C

With PPA; potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; chlorobenzene; acetonitrile;
DOI:10.1002/jhet.5570390611