tert-butyl (S)-2-(4-bromophenyl)-3,3-dicyano-5-methyl-2,3-dihydro-1H-pyrrole-1-carboxylate

Base Information

• Chemical Name: tert-butyl (S)-2-(4-bromophenyl)-3,3-dicyano-5-methyl-2,3-dihydro-1H-pyrrole-1-carboxylate
• CAS No.: 1252805-96-1
• Molecular Formula: C₁₈H₁₈BrN₃O₂
• Molecular Weight: 388.264

Synonyms:tert-butyl (S)-2-(4-bromophenyl)-3,3-dicyano-5-methyl-2,3-dihydro-1H-pyrrole-1-carboxylate

Chemical Property of tert-butyl (S)-2-(4-bromophenyl)-3,3-dicyano-5-methyl-2,3-dihydro-1H-pyrrole-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of tert-butyl (S)-2-(4-bromophenyl)-3,3-dicyano-5-methyl-2,3-dihydro-1H-pyrrole-1-carboxylate

There total 1 articles about tert-butyl (S)-2-(4-bromophenyl)-3,3-dicyano-5-methyl-2,3-dihydro-1H-pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-bromobenzylidenecarbamate (479423-43-3) + 2-(prop-2-yn-1-yl)propanedinitrile (130575-28-9) → tert-butyl (S)-2-(4-bromophenyl)-3,3-dicyano-5-methyl-2,3-dihydro-1H-pyrrole-1-carboxylate (1252805-96-1) + tert-butyl (R)-2-(4-bromophenyl)-3,3-dicyano-5-methyl-2,3-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:

tert-butyl 4-bromobenzylidenecarbamate; 2-(prop-2-yn-1-yl)propanedinitrile; With C₂₉H₂₈F₆N₄OS; In chloroform; at -60 ℃; for 22h;

With (Ph₃PAuNTf₂)₂.PhMe; toluene-4-sulfonic acid; In chloroform; water; at 20 ℃; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/chem.201001123

Reference yield: 95.0%

tert-butyl (S)-2-(4-bromophenyl)-3,3-dicyano-5-methyl-2,3-dihydro-1H-pyrrole-1-carboxylate (1252805-96-1) → (S)-2-(4-bromophenyl)-5-methyl-2H-pyrrole-3,3(4H)-dicarbonitrile

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/chem.201001123

upstream raw materials:

tert-butyl 4-bromobenzylidenecarbamate

2-(prop-2-yn-1-yl)propanedinitrile

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