(2-amino-4-methyl-5-(2-phenylethyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Base Information

Chemical Name:(2-amino-4-methyl-5-(2-phenylethyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone
CAS No.:1309872-65-8
Molecular Formula:C₂₃H₂₅NO₄S
Molecular Weight:411.522
Hs Code.:

Synonyms:(2-amino-4-methyl-5-(2-phenylethyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

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Chemical Property of (2-amino-4-methyl-5-(2-phenylethyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

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Technology Process of (2-amino-4-methyl-5-(2-phenylethyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

There total 5 articles about (2-amino-4-methyl-5-(2-phenylethyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1309872-55-6
(2-amino-4-methyl-5-(2-phenylethynyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

: 1309872-65-8
(2-amino-4-methyl-5-(2-phenylethyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; for 4h; under 2585.81 Torr; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.11.083

Reference yield:

: 901118-42-1
(2-amino-4-methylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

: 1309872-65-8
(2-amino-4-methyl-5-(2-phenylethyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / Inert atmosphere

2: bromine; sodium acetate; acetic acid / 20 °C / Inert atmosphere

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

4: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

5: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 2585.81 Torr / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; bromine; sodium acetate; hydrazine hydrate; acetic acid; triethylamine; In ethanol; N,N-dimethyl-formamide; 3: Sonogashira cross-coupling;
DOI:10.1016/j.bmcl.2010.11.083

Reference yield:

: 901118-50-1
2-[4-methyl-3-(3,4,5-trimethoxybenzoyl)-2-thienyl]-1H-isoindole-1,3(2H)-dione

: 1309872-65-8
(2-amino-4-methyl-5-(2-phenylethyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; sodium acetate; acetic acid / 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

4: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 2585.81 Torr / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; bromine; sodium acetate; hydrazine hydrate; acetic acid; triethylamine; In ethanol; N,N-dimethyl-formamide; 2: Sonogashira cross-coupling;
DOI:10.1016/j.bmcl.2010.11.083