3-(4-fluoro-2-methoxyphenyl)-7-(4-methylpyrimidin-5-yl)benzo[d]isoxazole

Base Information

Chemical Name:3-(4-fluoro-2-methoxyphenyl)-7-(4-methylpyrimidin-5-yl)benzo[d]isoxazole
CAS No.:1428880-35-6
Molecular Formula:C₁₉H₁₄FN₃O₂
Molecular Weight:335.337
Hs Code.:

Synonyms:3-(4-fluoro-2-methoxyphenyl)-7-(4-methylpyrimidin-5-yl)benzo[d]isoxazole

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Chemical Property of 3-(4-fluoro-2-methoxyphenyl)-7-(4-methylpyrimidin-5-yl)benzo[d]isoxazole

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Technology Process of 3-(4-fluoro-2-methoxyphenyl)-7-(4-methylpyrimidin-5-yl)benzo[d]isoxazole

There total 7 articles about 3-(4-fluoro-2-methoxyphenyl)-7-(4-methylpyrimidin-5-yl)benzo[d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1428881-60-0
3-(4-fluoro-2-methoxyphenyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]isoxazole

: 1439-09-4
5-bromo-4-methylpyrimidine

: 1428880-35-6
3-(4-fluoro-2-methoxyphenyl)-7-(4-methylpyrimidin-5-yl)benzo[d]isoxazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 90 ℃; for 14h; Inert atmosphere;

Reference yield:

: 1428881-56-4
(3-bromo-2-fluorophenyl)(4-fluoro-2-methoxyphenyl)methanol

: 1428880-35-6
3-(4-fluoro-2-methoxyphenyl)-7-(4-methylpyrimidin-5-yl)benzo[d]isoxazole

Guidance literature:: Multi-step reaction with 5 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2: pyridine; hydroxylamine hydrochloride / 1.5 h / Reflux

3: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 3 h / 70 °C

4: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); triethylamine / 1,4-dioxane / 13.5 h / 110 °C / Inert atmosphere; Sealed tube

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 14 h / 90 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; dichloro bis(acetonitrile) palladium(II); tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: (4-fluoro-2-methoxyphenyl)magnesium bromide

: 1428880-35-6
3-(4-fluoro-2-methoxyphenyl)-7-(4-methylpyrimidin-5-yl)benzo[d]isoxazole

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 0 °C

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

3: pyridine; hydroxylamine hydrochloride / 1.5 h / Reflux

4: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 3 h / 70 °C

5: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); triethylamine / 1,4-dioxane / 13.5 h / 110 °C / Inert atmosphere; Sealed tube

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 14 h / 90 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; dichloro bis(acetonitrile) palladium(II); tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;