4-isobutyloxybenzaldehyde oxime

Base Information

• Chemical Name: 4-isobutyloxybenzaldehyde oxime
• CAS No.: 882035-15-6
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 882035-15-6.mol

Synonyms:4-isobutyloxybenzaldehyde oxime

Chemical Property of 4-isobutyloxybenzaldehyde oxime

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (4-Isobutoxybenzyl)urea is an intermediate in the synthesis of 1,3-Bis(4-isobutoxybenzyl)urea (B448763), an impurity in the preparation of Pimavanserin (P441800), a drug used in the treatment of Parkinson’s disease and psychosis.

Technology Process of 4-isobutyloxybenzaldehyde oxime

There total 2 articles about 4-isobutyloxybenzaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

4-isobutoxybenzaldehyde (18962-07-7) → 4-isobutyloxybenzaldehyde oxime (882035-15-6)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; at 20 - 25 ℃; for 1h; Large scale;

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-isobutyloxybenzaldehyde oxime (882035-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6.83 h / -10 - 82 °C / Large scale

2: hydroxylamine / water; ethanol / 2.5 h / 20 - 77 °C / Large scale

With hydroxylamine; potassium carbonate; potassium iodide; In ethanol; water; N,N-dimethyl-formamide;

Reference yield: 100.0%

4-isobutyloxybenzaldehyde oxime (882035-15-6) → 1-[4-(2-methylpropyloxy)phenyl]methanamine (4734-09-2)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; acetic acid; In ethanol; at 22 ℃; under 1125.11 Torr; Large scale;

upstream raw materials:

4-hydroxy-benzaldehyde

4-isobutoxybenzaldehyde

Downstream raw materials:

1-[4-(2-methylpropyloxy)phenyl]methanamine

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

1-(isocyanatomethyl)-4-(2-methylpropoxy)benzene

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N’-(4-(2-methylpropyloxy)phenylmethyl)carbamide tartaric acid