2-[(2-hydroxypropyl)amino]-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

Base Information

Chemical Name:2-[(2-hydroxypropyl)amino]-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone
CAS No.:870960-79-5
Molecular Formula:C₂₁H₂₄N₄O₆
Molecular Weight:428.445
Hs Code.:

Synonyms:2-[(2-hydroxypropyl)amino]-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

Suppliers and Price of 2-[(2-hydroxypropyl)amino]-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(2-hydroxypropyl)amino]-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(2-hydroxypropyl)amino]-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

There total 8 articles about 2-[(2-hydroxypropyl)amino]-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 870960-14-8
2-([6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino)-5-(2-methylaziridin-1-yl)benzo-1,4-quinone

: 870960-79-5
2-[(2-hydroxypropyl)amino]-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 18h; pH=4;
DOI:10.1021/jm050559f

Reference yield:

: 247569-96-6
3-methoxy-4-(2-methoxyethoxy)benzonitrile

: 870960-79-5
2-[(2-hydroxypropyl)amino]-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

Guidance literature:: Multi-step reaction with 7 steps

1: NH₄NO₃; trifluoroacetic anhydride / CHCl₃ / 2 h / Heating

2: cyclohexene / Pd/C / ethanol / Heating

3: 7 h / Heating

4: 99 percent / AcOH / 1 h / 110 °C

5: 69 percent / aq. Ce(NH₄)2(NO₃)6 / CHCl₃; acetonitrile / 1 h / Heating

6: 90 percent / pyridine hydrochloride / tetrahydrofuran / 3 h / 40 °C / sonication

7: 69 percent / aq. HCl / tetrahydrofuran / 18 h / pH 4

With ammonium nitrate; hydrogenchloride; ammonium cerium(IV) nitrate; pyridine hydrochloride; acetic acid; trifluoroacetic anhydride; cyclohexene; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform; acetonitrile;
DOI:10.1021/jm050559f

Reference yield:

: 870959-50-5
5-methoxy-4-(2-methoxyethoxy)-2-nitrobenzonitrile

: 870960-79-5
2-[(2-hydroxypropyl)amino]-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone

Guidance literature:: Multi-step reaction with 6 steps

1: cyclohexene / Pd/C / ethanol / Heating

2: 7 h / Heating

3: 99 percent / AcOH / 1 h / 110 °C

4: 69 percent / aq. Ce(NH₄)2(NO₃)6 / CHCl₃; acetonitrile / 1 h / Heating

5: 90 percent / pyridine hydrochloride / tetrahydrofuran / 3 h / 40 °C / sonication

6: 69 percent / aq. HCl / tetrahydrofuran / 18 h / pH 4

With hydrogenchloride; ammonium cerium(IV) nitrate; pyridine hydrochloride; acetic acid; cyclohexene; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform; acetonitrile;
DOI:10.1021/jm050559f