3-(3,4-dichlorophenyl)-N,N-dimethyl-3-morpholinopropan-1-amine hydrochloride

Base Information

• Chemical Name: 3-(3,4-dichlorophenyl)-N,N-dimethyl-3-morpholinopropan-1-amine hydrochloride
• CAS No.: 1346460-40-9
• Molecular Formula: C₁₅H₂₂Cl₂N₂O*ClH
• Molecular Weight: 353.719
• Mol file: 1346460-40-9.mol

Synonyms:3-(3,4-dichlorophenyl)-N,N-dimethyl-3-morpholinopropan-1-amine hydrochloride

Chemical Property of 3-(3,4-dichlorophenyl)-N,N-dimethyl-3-morpholinopropan-1-amine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3,4-dichlorophenyl)-N,N-dimethyl-3-morpholinopropan-1-amine hydrochloride

There total 4 articles about 3-(3,4-dichlorophenyl)-N,N-dimethyl-3-morpholinopropan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.2%

→ 3-(3,4-dichlorophenyl)-N,N-dimethyl-3-morpholinopropan-1-amine hydrochloride (1346460-40-9)

Guidance literature:

With toluene-4-sulfonic acid; triethylamine; In acetonitrile; at 20 ℃; for 12h;

With potassium carbonate; In acetonitrile; at 20 ℃; for 8h;

With hydrogenchloride; In ethyl acetate;

Reference yield:

3-(3,4-dichlorophenyl)-N,N-dimethyl-3-morpholinopropan-1-amine → 3-(3,4-dichlorophenyl)-N,N-dimethyl-3-morpholinopropan-1-amine hydrochloride (1346460-40-9)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2014.08.045

Reference yield:

3-(dimethylamino)-1-(3,4-dichlorobenzene)-1-propanol (1225932-01-3,161229-01-2,147641-96-1) → 3-(3,4-dichlorophenyl)-N,N-dimethyl-3-morpholinopropan-1-amine hydrochloride (1346460-40-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

2: potassium carbonate / acetonitrile / 8 h / 70 °C

3: hydrogenchloride / ethanol / 1 h / 20 °C

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; acetonitrile;

DOI:10.1016/j.ejmech.2014.08.045

upstream raw materials:

3-(dimethylamino)-1-(3,4-dichlorobenzene)-1-propanol