1-(4-(2-(2-(naphthalen-2-ylacetyl)hydrazinocarbonyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea

Base Information

• Chemical Name: 1-(4-(2-(2-(naphthalen-2-ylacetyl)hydrazinocarbonyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea
• CAS No.: 1610930-19-2
• Molecular Formula: C₃₂H₂₃ClF₃N₅O₄
• Molecular Weight: 634.014

Synonyms:1-(4-(2-(2-(naphthalen-2-ylacetyl)hydrazinocarbonyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea

Chemical Property of 1-(4-(2-(2-(naphthalen-2-ylacetyl)hydrazinocarbonyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea

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Technology Process of 1-(4-(2-(2-(naphthalen-2-ylacetyl)hydrazinocarbonyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea

There total 5 articles about 1-(4-(2-(2-(naphthalen-2-ylacetyl)hydrazinocarbonyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1‐(4‐chloro‐3‐(trifluoromethyl)phenyl)‐3‐(4‐((2‐(hydrazinecarbonyl)pyridin‐4‐yl)oxy)phenyl)urea + 2-naphthylacetic acid (581-96-4) → 1-(4-(2-(2-(naphthalen-2-ylacetyl)hydrazinocarbonyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea (1610930-19-2)

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.cclet.2014.03.020

Reference yield:

4-Chloro-pyridine-2-carboxylic acid methyl ester (24484-93-3) → 1-(4-(2-(2-(naphthalen-2-ylacetyl)hydrazinocarbonyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea (1610930-19-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 8 h / 80 °C / Inert atmosphere

2.1: dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: hydrazine hydrate / deuteromethanol / 10 h / Reflux

4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With potassium tert-butylate; hydrazine hydrate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; deuteromethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.cclet.2014.03.020

Reference yield:

4-amino-phenol (123-30-8) → 1-(4-(2-(2-(naphthalen-2-ylacetyl)hydrazinocarbonyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea (1610930-19-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 8 h / 80 °C / Inert atmosphere

2.1: dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: hydrazine hydrate / deuteromethanol / 10 h / Reflux

4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With potassium tert-butylate; hydrazine hydrate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; deuteromethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.cclet.2014.03.020

upstream raw materials:

4-Chloro-pyridine-2-carboxylic acid methyl ester

4-amino-phenol

methyl 4‐(4‐aminophenoxy)picolinate

methyl 4‐(4‐(3‐(4‐chloro‐3‐(trifluoromethyl)phenyl)ureido)phenoxy)picolinate

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