2-amino-4-(4-cyanophenyl)-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitrile

Base Information

• Chemical Name: 2-amino-4-(4-cyanophenyl)-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitrile
• CAS No.: 339580-47-1
• Molecular Formula: C₁₇H₁₃N₃O₂
• Molecular Weight: 291.309

Synonyms:2-amino-4-(4-cyanophenyl)-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitrile

Chemical Property of 2-amino-4-(4-cyanophenyl)-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 2-amino-4-(4-cyanophenyl)-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitrile

There total 3 articles about 2-amino-4-(4-cyanophenyl)-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,3-cylohexanedione (504-02-9) + 4-cyanobenzaldehyde (105-07-7) + malononitrile (109-77-3) → 2-amino-4-(4-cyanophenyl)-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitrile (339580-47-1)

Guidance literature:

With Lipase from Thermomyces lanuginosus immobilized on particle silica gel; In water; dimethyl sulfoxide; at 45 ℃; for 12h;

DOI:10.1016/j.bioorg.2020.103888

Reference yield: 81.0%

2-amino-4-(4-bromophenyl)-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitrile (299167-34-3) + potassium ferrocyanide → 2-amino-4-(4-cyanophenyl)-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitrile (339580-47-1)

Guidance literature:

With copper(l) iodide; per-6-amino-β-cyclodextrin; sodium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 130 ℃; for 36h; Microwave irradiation;

DOI:10.1039/c2nj40556c

Reference yield:

→ 2-amino-4-(4-cyanophenyl)-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitrile (339580-47-1)

Guidance literature:

With dmap; Reflux;

upstream raw materials:

1,3-cylohexanedione

4-cyanobenzaldehyde

malononitrile

2-amino-4-(4-bromophenyl)-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitrile

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