4-(2-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenoxy}ethyl)morpholine

Base Information

Chemical Name:4-(2-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenoxy}ethyl)morpholine
CAS No.:1226917-07-2
Molecular Formula:C₂₆H₂₆F₃N₅O₄
Molecular Weight:529.519
Hs Code.:

Synonyms:4-(2-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenoxy}ethyl)morpholine

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Chemical Property of 4-(2-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenoxy}ethyl)morpholine

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Technology Process of 4-(2-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenoxy}ethyl)morpholine

There total 9 articles about 4-(2-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenoxy}ethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 622-40-2
2-(morpholin-4-yl)ethanol

: 1225380-79-9
3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]-phenol

: 1226917-07-2
4-(2-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenoxy}ethyl)morpholine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield:

: 402-61-9
5-methyl-1H-pyrazole-3-carboxylic acid

: 1226917-07-2
4-(2-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenoxy}ethyl)morpholine

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 7 h / 20 - 140 °C

2: potassium tert-butylate / tetrahydrofuran / 15 h / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h / 20 °C

With di-isopropyl azodicarboxylate; potassium tert-butylate; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 7781-98-8
ethyl-3-hydroxybenzoate

: 1226917-07-2
4-(2-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenoxy}ethyl)morpholine

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

2: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 h / 20 °C

4: potassium tert-butylate / tetrahydrofuran / 15 h / 0 - 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

6: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; carbon tetrabromide; di-isopropyl azodicarboxylate; potassium tert-butylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;