Benzenemethanol, 2,6-difluoro-3-hydroxy-

Base Information

• Chemical Name: Benzenemethanol, 2,6-difluoro-3-hydroxy-
• CAS No.: 866028-20-8
• Molecular Formula: C7H6 F2 O2
• Molecular Weight: 160.12
• Mol file: 866028-20-8.mol

Synonyms:2,4-Difluoro-3-(hydroxymethyl)phenol

Chemical Property of Benzenemethanol, 2,6-difluoro-3-hydroxy-

Chemical Property:

• PSA: 40.46000
• LogP: 1.16270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, 2,6-difluoro-3-hydroxy-

There total 1 articles about Benzenemethanol, 2,6-difluoro-3-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2,6-difluoro-3-hydroxy-benzaldehyde (152434-88-3) → 2,4-difluoro-3-(hydroxymethyl)phenol (866028-20-8)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; hexane; at 0 - 20 ℃; for 1.5h;

Reference yield: 47.0%

2,4-difluoro-3-(hydroxymethyl)phenol (866028-20-8) → 3-(bromomethyl)-2,4-difluorophenol (866028-21-9)

Guidance literature:

With phosphorus tribromide; In diethyl ether; dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

2-(2-(2-chloroethoxy)ethoxy)ethyl methanesulfonate (894424-79-4) + 2,4-difluoro-3-(hydroxymethyl)phenol (866028-20-8) → C13H17ClF2O4

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 4h;

DOI:10.1021/acsmedchemlett.7b00116

upstream raw materials:

2,6-difluoro-3-hydroxy-benzaldehyde

Downstream raw materials:

3-(bromomethyl)-2,4-difluorophenol

Refernces