diethyl 4-(4-fluorobenzoyl)-5-(4-methoxyphenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

Base Information

Chemical Name:diethyl 4-(4-fluorobenzoyl)-5-(4-methoxyphenyl)-1H-pyrrole-2,2(5H)-dicarboxylate
CAS No.:1325732-09-9
Molecular Formula:C₂₄H₂₄FNO₆
Molecular Weight:441.456
Hs Code.:

Synonyms:diethyl 4-(4-fluorobenzoyl)-5-(4-methoxyphenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

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Chemical Property of diethyl 4-(4-fluorobenzoyl)-5-(4-methoxyphenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

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Technology Process of diethyl 4-(4-fluorobenzoyl)-5-(4-methoxyphenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

There total 7 articles about diethyl 4-(4-fluorobenzoyl)-5-(4-methoxyphenyl)-1H-pyrrole-2,2(5H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₁₅H₁₉NO₅

: 54012-23-6
1-(4-fluorophenyl)prop-2-yn-1-one

: 1325732-09-9
diethyl 4-(4-fluorobenzoyl)-5-(4-methoxyphenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

Guidance literature:: With (S,S_p)-R-Phosferrox; copper(II) acetate monohydrate; In dichloromethane; at 0 ℃; for 0.5h; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1039/c5cy00422e

Reference yield: 72.0%

: 6829-40-9
aminomalonic acid diethyl ester

: 19115-30-1
1-(4-methoxyphenyl)-2-propyn-1-ol

: 54012-23-6
1-(4-fluorophenyl)prop-2-yn-1-one

: 1325732-09-9
diethyl 4-(4-fluorobenzoyl)-5-(4-methoxyphenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

Guidance literature:: With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; In toluene; at 20 ℃; for 36h; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1021/ol201898x

Reference yield:

: 3798-61-6,179249-16-2
1-(4-fluorophenyl)prop-2-yn-1-ol

: 1325732-09-9
diethyl 4-(4-fluorobenzoyl)-5-(4-methoxyphenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 0 - 20 °C

2: (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate / toluene / 36 h / 20 °C / Molecular sieve

With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; manganese(IV) oxide; In dichloromethane; toluene;
DOI:10.1021/ol201898x