(R)-ethyl 3-amino-4-pentynoate

Base Information

• Chemical Name: (R)-ethyl 3-amino-4-pentynoate
• CAS No.: 188853-28-3
• Molecular Formula: C₇H₁₁NO₂
• Molecular Weight: 141.17
• Mol file: 188853-28-3.mol

Synonyms:(R)-ethyl 3-amino-4-pentynoate

Chemical Property of (R)-ethyl 3-amino-4-pentynoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-ethyl 3-amino-4-pentynoate

There total 1 articles about (R)-ethyl 3-amino-4-pentynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 3-(N-phenylacetyl)amino-4-pentynoate (215738-17-3) → (R)-ethyl 3-amino-4-pentynoate (188853-28-3) + ethyl (S)-3-(N-phenylacetyl)amino-4-pentynoate

Guidance literature:

With immobilzed Penicillin G amidohydrolase; potassium hydrogencarbonate; In phosphate buffer; at 20 ℃; for 24h; pH=7.5; Enzymatic reaction;

DOI:10.1016/S0968-0896(99)00155-8

Reference yield:

(R)-ethyl 3-amino-4-pentynoate (188853-28-3) → (3R)-ethyl 3-<<4-<<4-(aminoiminomethyl)phenyl>amino>-1,4-dioxobutyl>amino>-4-pentynoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP, diisopropylethylamine / dimethylformamide / 1 h

2: 3.2M aq. (NH₄)2SO₄, 0.1M phosphate buffer / 20 h / 23 °C / porcine liver esterase

With dmap; ammonium sulfate; phosphate buffer; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00013a014

Reference yield:

C16H21N3O5 (1027293-42-0) + (R)-ethyl 3-amino-4-pentynoate (188853-28-3) → (3R)-ethyl 3-<<4-<<4-(aminoiminomethyl)phenyl>amino>-1,4-dioxobutyl>amino>-4-pentynoate (169275-98-3)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 1h;

DOI:10.1021/jm00013a014

upstream raw materials:

ethyl 3-(N-phenylacetyl)amino-4-pentynoate

Downstream raw materials:

(3R)-ethyl 3-<<4-<<4-(aminoiminomethyl)phenyl>amino>-1,4-dioxobutyl>amino>-4-pentynoate