(S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-hexylurea

Base Information

Chemical Name:(S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-hexylurea
CAS No.:1417654-28-4
Molecular Formula:C₂₂H₂₉I₂N₃O₃
Molecular Weight:637.3
Hs Code.:

Synonyms:(S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-hexylurea

Suppliers and Price of (S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-hexylurea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-hexylurea

Chemical Property:

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Technology Process of (S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-hexylurea

There total 7 articles about (S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-hexylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₄₅I₂N₃O₆

: 1417654-28-4
(S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-hexylurea

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; for 0.25h;

Reference yield:

: 1417654-01-3
(S)-tert-butyl (1-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)-3-hydroxypropan-2-yl)carbamate

: 1417654-28-4
(S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-hexylurea

Guidance literature:: Multi-step reaction with 5 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide / toluene / 4.5 h / 20 °C / Cooling with ice

2: sodium azide / N,N-dimethyl-formamide / 24 h / 80 °C

3: triphenylphosphine / tetrahydrofuran; water / 18 h / 20 °C

4: tetrahydrofuran / 0.5 h

5: triethylsilane; trifluoroacetic acid / dichloromethane / 0.25 h

With triethylsilane; sodium azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1417654-00-2
(S)-tert-butyl (1-hydroxy-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propan-2-yl)carbamate

: 1417654-28-4
(S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-hexylurea

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide / toluene / 4.5 h / 20 °C / Cooling with ice

3: sodium azide / N,N-dimethyl-formamide / 24 h / 80 °C

4: triphenylphosphine / tetrahydrofuran; water / 18 h / 20 °C

5: tetrahydrofuran / 0.5 h

6: triethylsilane; trifluoroacetic acid / dichloromethane / 0.25 h

With triethylsilane; sodium azide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;