(S)-TERT-BUTYL 1-(HYDROXYAMINO)-3-(4-BROMOPHENYL)-1-OXOPROPAN-2-YLCARBAMATE

Base Information

• Chemical Name: (S)-TERT-BUTYL 1-(HYDROXYAMINO)-3-(4-BROMOPHENYL)-1-OXOPROPAN-2-YLCARBAMATE
• CAS No.: 864876-00-6
• Molecular Formula: C₁₄H₁₉BrN₂O₄
• Molecular Weight: 359.22
• Mol file: 864876-00-6.mol

Synonyms:(S)-TERT-BUTYL 1-(HYDROXYAMINO)-3-(4-BROMOPHENYL)-1-OXOPROPAN-2-YLCARBAMATE

Chemical Property of (S)-TERT-BUTYL 1-(HYDROXYAMINO)-3-(4-BROMOPHENYL)-1-OXOPROPAN-2-YLCARBAMATE

Chemical Property:

• PSA: 87.66000
• LogP: 3.17210

Purity/Quality:

98% ^*data from raw suppliers

(S)-TERT-BUTYL-1-(HYDROXYAMINO)-3-(4-BROMOPHENYL)-1-OXOPROPAN-2-YLCARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-TERT-BUTYL 1-(HYDROXYAMINO)-3-(4-BROMOPHENYL)-1-OXOPROPAN-2-YLCARBAMATE

There total 3 articles about (S)-TERT-BUTYL 1-(HYDROXYAMINO)-3-(4-BROMOPHENYL)-1-OXOPROPAN-2-YLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

methyl (±)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate (132067-41-5) → tert-butyl (3-(4-bromophenyl)-1-(hydroxyamino)-1-oxopropan-2-yl)carbamate (864876-00-6)

Guidance literature:

With hydroxylamine hydrochloride; potassium hydroxide; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.01.015

Reference yield:

p-bromo-DL-phenylalanine (14091-15-7) → tert-butyl (3-(4-bromophenyl)-1-(hydroxyamino)-1-oxopropan-2-yl)carbamate (864876-00-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / Reflux

2: tetrahydrofuran; water / 20 °C

3: hydroxylamine hydrochloride; potassium hydroxide / methanol / 20 °C / Inert atmosphere

With sulfuric acid; hydroxylamine hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.ejmech.2016.01.015

Reference yield:

ethyl 2-amino-3-(4-bromophenyl) propanoate (166967-59-5) → tert-butyl (3-(4-bromophenyl)-1-(hydroxyamino)-1-oxopropan-2-yl)carbamate (864876-00-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; water / 20 °C

2: hydroxylamine hydrochloride; potassium hydroxide / methanol / 20 °C / Inert atmosphere

With hydroxylamine hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.ejmech.2016.01.015

upstream raw materials:

methyl (±)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate

p-bromo-DL-phenylalanine

ethyl 2-amino-3-(4-bromophenyl) propanoate