(R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-4-methyl-1-oxa-4,7-diaza-cyclohexadecane-2,5,8-trione

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Chemical Name:(R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-4-methyl-1-oxa-4,7-diaza-cyclohexadecane-2,5,8-trione
CAS No.:161979-04-0
Molecular Formula:C₂₇H₄₃IN₂O₅Si
Molecular Weight:630.639
Hs Code.:

Synonyms:(R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-4-methyl-1-oxa-4,7-diaza-cyclohexadecane-2,5,8-trione

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Chemical Property of (R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-4-methyl-1-oxa-4,7-diaza-cyclohexadecane-2,5,8-trione

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Technology Process of (R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-4-methyl-1-oxa-4,7-diaza-cyclohexadecane-2,5,8-trione

There total 9 articles about (R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-4-methyl-1-oxa-4,7-diaza-cyclohexadecane-2,5,8-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-2-methylamino-propionic acid 8-(carboxymethyl-carbamoyl)-octyl ester; compound with trifluoro-acetic acid

: 161979-04-0
(R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-4-methyl-1-oxa-4,7-diaza-cyclohexadecane-2,5,8-trione

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 0 - 28 ℃; for 15h; Yield given;
DOI:10.1016/S0040-4020(01)81206-0

Reference yield:

: 3937-56-2
1,9-Nonanediol

: 161979-04-0
(R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-4-methyl-1-oxa-4,7-diaza-cyclohexadecane-2,5,8-trione

Guidance literature:: Multi-step reaction with 8 steps

1: 52 percent / 60percent NaH / tetrahydrofuran; hexane / 1.5 h / Ambient temperature

2: 42.7 mg / SO₃*pyridine, Et₃N / dimethylsulfoxide / 16 h / Ambient temperature

3: 80percent NaClO₂, NaHPO₄*2H₂O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 0.17 h / Ambient temperature

4: 93 percent / DEPC, Et₃N / dimethylformamide / 0.67 h / 0 °C

5: 99 percent / 47percent aq. HF / acetonitrile / 0.33 h / 0 °C

6: 95 percent / DCC, DMAP / CH₂Cl₂ / 0.67 h / -20 °C

7: CH₂Cl₂ / 1.5 h / Ambient temperature

8: Bop-Cl, Et₃N / CH₂Cl₂ / 15 h / 0 - 28 °C

With dmap; sodium chlorite; 2-methyl-but-2-ene; pyridine-SO₃ complex; hydrogen fluoride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; diethyl dicarbonate; In tetrahydrofuran; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)81206-0

Reference yield:

: 157730-99-9
9-(tert-butyldimethylsilanyloxy)-1-nonanol

: 161979-04-0
(R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-4-methyl-1-oxa-4,7-diaza-cyclohexadecane-2,5,8-trione

Guidance literature:: Multi-step reaction with 7 steps

1: 42.7 mg / SO₃*pyridine, Et₃N / dimethylsulfoxide / 16 h / Ambient temperature

2: 80percent NaClO₂, NaHPO₄*2H₂O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 0.17 h / Ambient temperature

3: 93 percent / DEPC, Et₃N / dimethylformamide / 0.67 h / 0 °C

4: 99 percent / 47percent aq. HF / acetonitrile / 0.33 h / 0 °C

5: 95 percent / DCC, DMAP / CH₂Cl₂ / 0.67 h / -20 °C

6: CH₂Cl₂ / 1.5 h / Ambient temperature

7: Bop-Cl, Et₃N / CH₂Cl₂ / 15 h / 0 - 28 °C

With dmap; sodium chlorite; 2-methyl-but-2-ene; pyridine-SO₃ complex; hydrogen fluoride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; dicyclohexyl-carbodiimide; diethyl dicarbonate; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)81206-0