N^α-Benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Lithium Salt

Base Information

• Chemical Name: N^α-Benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Lithium Salt
• CAS No.: 87136-46-7
• Molecular Formula: C₃₁H₄₇N₆O₁₀*Li
• Molecular Weight: 670.689

Synonyms:N^α-Benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Lithium Salt

Chemical Property of N^α-Benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Lithium Salt

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N^α-Benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Lithium Salt

There total 7 articles about N^α-Benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Lithium Salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Benzyloxycarbonyl-L-asparaginyl-L-leucine Methyl Ester (14317-83-0) → Nα-Benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Lithium Salt (87136-46-7)

Guidance literature:

Multi-step reaction with 3 steps

1: HCOOH / Pd/C

2: 24 percent / N-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / Ambient temperature

3: LiOH / 2-methyl-propan-2-ol; H₂O

With lithium hydroxide; formic acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1021/jo00170a015

Reference yield:

methyl (L)-leucinate hydrochloride (7517-19-3) → Nα-Benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Lithium Salt (87136-46-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 50 percent / N-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / 0 - 25 °C

2: HCOOH / Pd/C

3: 24 percent / N-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / Ambient temperature

4: LiOH / 2-methyl-propan-2-ol; H₂O

With lithium hydroxide; formic acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1021/jo00170a015

Reference yield:

Nα-Benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Methyl Ester (87136-45-6) → Nα-Benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Lithium Salt (87136-46-7)

Guidance literature:

With lithium hydroxide; In water; tert-butyl alcohol;

DOI:10.1021/jo00170a015

upstream raw materials:

N^α-Benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucine Methyl Ester

N^α-Benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysylglycine Methyl Ester

N-Benzyloxycarbonyl-L-asparaginyl-L-leucine Methyl Ester

H-Asn-Leu-OMe

Downstream raw materials:

N-Benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysylglycyl-L-asparaginyl-L-leucyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-arginyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamic Acid α-Methyl Ester p-Toluenesulfonate Salt

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