Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Base Information

• Chemical Name: Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester
• CAS No.: 81244-09-9
• Molecular Formula: C₆₇H₆₄N₃O₁₀PS₂
• Molecular Weight: 1166.37

Synonyms:Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Chemical Property of Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

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Technology Process of Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

There total 10 articles about Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

cyclohexylammonium S,S-diphenyl phosphorodithioate (125292-09-3) + 1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-1H-pyrimidin-2-one (81244-05-5) → Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester (81244-09-9)

Guidance literature:

With 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; In pyridine; 1.) 30 min; 2.) 1 h;

DOI:10.1016/0040-4020(84)85114-5

Reference yield: 77.0%

cyclohexylammonium S,S-diphenyl phosphorodithioate (67941-87-1) + 1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-1H-pyrimidin-2-one (81244-05-5) → Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester (81244-09-9)

Guidance literature:

With pyridine; 4,6-dimethoxybenzene-1,3-bis(sulfonyl) chloride; for 2h;

DOI:10.1246/cl.1982.15

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester (81244-09-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / triethylamine / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: 97 percent / p-toluenesulfonic acid / dioxane

3: 93 percent / tetraethylammonium chloride; KF / acetonitrile; H₂O / 20 h / Ambient temperature

4: 97 percent

5: 77 percent / 2,4-dimethoxy-benzene-1,5-disulfonyl chloride(DMS); pyridine / 2 h

With pyridine; potassium fluoride; 4,6-dimethoxybenzene-1,3-bis(sulfonyl) chloride; tetraethylammonium chloride; toluene-4-sulfonic acid; triethylamine; dmap; In 1,4-dioxane; dichloromethane; water; acetonitrile;

DOI:10.1246/cl.1982.15

upstream raw materials:

cyclohexylammonium S,S-diphenyl phosphorodithioate

1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-1H-pyrimidin-2-one

cyclohexylammonium S,S-diphenyl phosphorodithioate

3,4-dihydro-2H-pyran

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