1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Base Information

Chemical Name:1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
CAS No.:1381763-73-0
Molecular Formula:C₂₇H₃₄ClF₃N₈O₄
Molecular Weight:627.066
Hs Code.:

1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Synonyms:1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

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Chemical Property of 1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

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Technology Process of 1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

There total 4 articles about 1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21950-36-7
5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine

: 1381763-73-0
1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Reflux

2: potassium carbonate / acetonitrile / 72 h / 80 °C

3: hydrazine hydrate / ethanol / 2 h / Reflux

4: triethylamine / dichloromethane / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 1381761-99-4
2-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)propyl)isoindoline-1,3-dione

: 1381763-73-0
1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 72 h / 80 °C

2: hydrazine hydrate / ethanol / 2 h / Reflux

3: triethylamine / dichloromethane / 1 h / 20 °C

With potassium carbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 80860-44-2
2-[[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl]-2,3-dihydro-1H-isoindol-1,3-dione

: 1381763-73-0
1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / ethanol / 3 h / 20 °C / Reflux

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Reflux

3: potassium carbonate / acetonitrile / 72 h / 80 °C

4: hydrazine hydrate / ethanol / 2 h / Reflux

5: triethylamine / dichloromethane / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;