5-(4-chlorobenzoyl)-4-morpholino-4-thioxo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine

Base Information

Chemical Name:5-(4-chlorobenzoyl)-4-morpholino-4-thioxo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine
CAS No.:380420-01-9
Molecular Formula:C₂₁H₁₇ClF₃N₄O₂PS
Molecular Weight:512.88
Hs Code.:

Synonyms:5-(4-chlorobenzoyl)-4-morpholino-4-thioxo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine

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Chemical Property of 5-(4-chlorobenzoyl)-4-morpholino-4-thioxo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine

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Technology Process of 5-(4-chlorobenzoyl)-4-morpholino-4-thioxo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine

There total 5 articles about 5-(4-chlorobenzoyl)-4-morpholino-4-thioxo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 110-91-8,99108-56-2
morpholine

: 420849-27-0
5-(4-chlorobenzoyl)-4-bromo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine

: 380420-01-9
5-(4-chlorobenzoyl)-4-morpholino-4-thioxo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine

Guidance literature:: morpholine; 5-(4-chlorobenzoyl)-4-bromo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine; In pyridine; triethylamine; at 0 ℃; for 0.5h;

With sulfur; In pyridine; triethylamine; at 85 ℃; for 9h;
DOI:10.1002/hc.10000

Reference yield:

: 121-17-5
2-chloro-3-nitro-5-trifluoromethylbenzene

: 380420-01-9
5-(4-chlorobenzoyl)-4-morpholino-4-thioxo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 75 percent / K₂CO₃ / dimethylformamide / 1.5 h / 100 - 110 °C

2.1: 63 percent / Fe powder; HOAc / propan-2-ol / 1.5 h / Heating

3.1: pyridine / 3.5 h / -5 - 20 °C

4.1: 67 percent / phosphorus tribromide / triethylamine; toluene / 1 h / -20 °C

5.1: triethylamine; pyridine / 0.5 h / 0 °C

5.2: 59 percent / sulfur / triethylamine; pyridine / 9 h / 85 °C

With phosphorus tribromide; iron; potassium carbonate; acetic acid; In pyridine; triethylamine; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1002/hc.10000

Reference yield:

: 25373-61-9
1-(2-nitro-4-trifluoromethylphenyl)-1H-imidazole

: 380420-01-9
5-(4-chlorobenzoyl)-4-morpholino-4-thioxo-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 63 percent / Fe powder; HOAc / propan-2-ol / 1.5 h / Heating

2.1: pyridine / 3.5 h / -5 - 20 °C

3.1: 67 percent / phosphorus tribromide / triethylamine; toluene / 1 h / -20 °C

4.1: triethylamine; pyridine / 0.5 h / 0 °C

4.2: 59 percent / sulfur / triethylamine; pyridine / 9 h / 85 °C

With phosphorus tribromide; iron; acetic acid; In pyridine; triethylamine; isopropyl alcohol; toluene;
DOI:10.1002/hc.10000