4-(4-{4-[2-(4-benzyloxycarbonylamino-butane-1-sulfonylamino)-2-carboxy-ethyl]-phenoxy}-butyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(4-{4-[2-(4-benzyloxycarbonylamino-butane-1-sulfonylamino)-2-carboxy-ethyl]-phenoxy}-butyl)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:464175-36-8
Molecular Formula:C₃₅H₅₁N₃O₉S
Molecular Weight:689.871
Hs Code.:

4-(4-{4-[2-(4-benzyloxycarbonylamino-butane-1-sulfonylamino)-2-carboxy-ethyl]-phenoxy}-butyl)-piperidine-1-carboxylic acid <i>tert</i>-butyl ester

Synonyms:4-(4-{4-[2-(4-benzyloxycarbonylamino-butane-1-sulfonylamino)-2-carboxy-ethyl]-phenoxy}-butyl)-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-(4-{4-[2-(4-benzyloxycarbonylamino-butane-1-sulfonylamino)-2-carboxy-ethyl]-phenoxy}-butyl)-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-(4-{4-[2-(4-benzyloxycarbonylamino-butane-1-sulfonylamino)-2-carboxy-ethyl]-phenoxy}-butyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 11 articles about 4-(4-{4-[2-(4-benzyloxycarbonylamino-butane-1-sulfonylamino)-2-carboxy-ethyl]-phenoxy}-butyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 464175-33-5
4-(4-{4-[2-(4-benzyloxycarbonylamino-butane-1-sulfonylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-butyl)-piperidine-1-carboxylic acid tert-butyl ester

: 464175-36-8
4-(4-{4-[2-(4-benzyloxycarbonylamino-butane-1-sulfonylamino)-2-carboxy-ethyl]-phenoxy}-butyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 18h;
DOI:10.1006/bioo.2001.1227

Reference yield:

: 142373-56-6
4-{4-[4-((S)-2-Benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-butyl}-piperidine-1-carboxylic acid tert-butyl ester

: 464175-36-8
4-(4-{4-[2-(4-benzyloxycarbonylamino-butane-1-sulfonylamino)-2-carboxy-ethyl]-phenoxy}-butyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / hydrogen / 10 percent Pd/C / methanol / 1 h

2: 58 percent / NaHCO₃ / ethyl acetate / 65 h / 40 - 45 °C

3: 93 percent / LiOH / methanol; tetrahydrofuran; H₂O / 18 h / 20 °C

With lithium hydroxide; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; ethyl acetate;
DOI:10.1006/bioo.2001.1227

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 464175-36-8
4-(4-{4-[2-(4-benzyloxycarbonylamino-butane-1-sulfonylamino)-2-carboxy-ethyl]-phenoxy}-butyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / TEA / CH₂Cl₂ / 20 h / 20 °C

2: 53 percent / NaH; KI / dimethylformamide / 72 h / 40 - 45 °C

3: 100 percent / Cs₂CO₃ / dimethylformamide / 18 h / 20 °C

4: 92 percent / hydrogen / 10 percent Pd/C / methanol / 1 h

5: 58 percent / NaHCO₃ / ethyl acetate / 65 h / 40 - 45 °C

6: 93 percent / LiOH / methanol; tetrahydrofuran; H₂O / 18 h / 20 °C

With lithium hydroxide; TEA; hydrogen; sodium hydride; sodium hydrogencarbonate; caesium carbonate; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1006/bioo.2001.1227