2-(3-Chlorophenyl)morpholine

Base Information

• Chemical Name: 2-(3-Chlorophenyl)morpholine
• CAS No.: 61151-63-1
• Molecular Formula: C10H12 Cl N O
• Molecular Weight: 197.66
• European Community (EC) Number: 843-221-5
• Mol file: 61151-63-1.mol

Synonyms:2-(3-CHLOROPHENYL)MORPHOLINE;61151-63-1;2-(3-Chlorophenyl)-morpholine HCl;SCHEMBL11681496;MFCD09901454;AKOS009358883;2-(3-CHLOROPHENYL)-MORPHOLINE;AB54615;NS-01984;CS-0143946;C78347;EN300-130511;F2148-1701;Z397586758

Chemical Property of 2-(3-Chlorophenyl)morpholine

Chemical Property:

• PSA: 21.26000
• LogP: 2.32970
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 197.0607417
• Heavy Atom Count: 13
• Complexity: 165

Purity/Quality:

98%min ^*data from raw suppliers

2-(3-chlorophenyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1)C2=CC(=CC=C2)Cl

Technology Process of 2-(3-Chlorophenyl)morpholine

There total 3 articles about 2-(3-Chlorophenyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzyl-2-(3-chloro-phenyl)-morpholine (62459-71-6) → 2-(3-chloro-phenyl)-morpholine (61151-63-1)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; at 20 ℃; for 5h; under 2068.6 Torr;

Reference yield:

1-bromo-3-chlorobenzene (108-37-2) → 2-(3-chloro-phenyl)-morpholine (61151-63-1)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) Mg, Et₂O, (ii) /BRN= 1736038/

2: toluene / 6 h / Heating

3: H₂, aq. HCl / Pd-C / methanol; H₂O / 5 h / 20 °C / 2068.6 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; toluene;

Reference yield:

1-[2-bromo-1-(2-chloro-ethoxy)-ethyl]-3-chloro-benzene (61151-60-8) → 2-(3-chloro-phenyl)-morpholine (61151-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 6 h / Heating

2: H₂, aq. HCl / Pd-C / methanol; H₂O / 5 h / 20 °C / 2068.6 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; toluene;

upstream raw materials:

4-benzyl-2-(3-chloro-phenyl)-morpholine

1-bromo-3-chlorobenzene

1-[2-bromo-1-(2-chloro-ethoxy)-ethyl]-3-chloro-benzene