N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-[1,1'-biphenyl]-4-carboxamide

Base Information

Chemical Name:N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-[1,1'-biphenyl]-4-carboxamide
CAS No.:1569314-82-4
Molecular Formula:C₂₃H₁₉N₃O₆S
Molecular Weight:465.486
Hs Code.:

Synonyms:N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-[1,1'-biphenyl]-4-carboxamide

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Chemical Property of N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-[1,1'-biphenyl]-4-carboxamide

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Technology Process of N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-[1,1'-biphenyl]-4-carboxamide

There total 7 articles about N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-[1,1'-biphenyl]-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1569314-56-2
3-(6-([1,1'-biphenyl]-4-ylcarboxamido)-1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)propanoic acid

: 1569314-82-4
N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-[1,1'-biphenyl]-4-carboxamide

Guidance literature:: 3-(6-([1,1'-biphenyl]-4-ylcarboxamido)-1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)propanoic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With hydroxylamine hydrochloride; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/j.bmc.2014.01.045

Reference yield:

: 22952-24-5
6-nitrosaccharin

: 1569314-82-4
N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-[1,1'-biphenyl]-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 4 h / 60 - 80 °C

2.1: hydrogenchloride / water / 100 °C

3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 4 h / 20 °C / 760.05 Torr

4.1: sodium hydrogencarbonate / tetrahydrofuran / 8 h / 20 °C

5.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / 0 °C

5.2: 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.01.045

Reference yield:

: 178755-49-2
3-(6-Nitro-1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-propionic acid ethyl ester

: 1569314-82-4
N-(2-(3-(hydroxyamino)-3-oxopropyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-[1,1'-biphenyl]-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 100 °C

2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 4 h / 20 °C / 760.05 Torr

3.1: sodium hydrogencarbonate / tetrahydrofuran / 8 h / 20 °C

4.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / 0 °C

4.2: 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; water;
DOI:10.1016/j.bmc.2014.01.045