(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl 2-methylalaninate hydrochloride

Base Information

Chemical Name:(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl 2-methylalaninate hydrochloride
CAS No.:1311319-03-5
Molecular Formula:C₂₅H₂₉F₃N₄O₄S*ClH
Molecular Weight:575.052
Hs Code.:

(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl 2-methylalaninate hydrochloride

Synonyms:(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl 2-methylalaninate hydrochloride

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Chemical Property of (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl 2-methylalaninate hydrochloride

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Technology Process of (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl 2-methylalaninate hydrochloride

There total 7 articles about (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl 2-methylalaninate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311318-81-6
(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl 2-methylalaninate

: 1311319-03-5
(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl 2-methylalaninate hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1232169-35-5,1311319-13-7
2-fluoro-N-(thiazolo[4,5-c]pyridin-2-yl)-5-(trifluoromethyl)benzamide

: 1311319-03-5
(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl 2-methylalaninate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; tetra-(n-butyl)ammonium iodide; tetraethylammonium iodide / toluene / 12 h / Reflux

2.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

2.2: 4 h / 20 °C

3.1: dmap; triethylamine; HATU / N,N-dimethyl-formamide / 50 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

4.2: pH 9

5.1: hydrogenchloride / dichloromethane; diethyl ether / 2 h / 20 °C

With hydrogenchloride; dmap; tetraethylammonium iodide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1231955-18-2
N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide

: 1311319-03-5
(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl 2-methylalaninate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; triethylamine; HATU / N,N-dimethyl-formamide / 50 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: pH 9

3.1: hydrogenchloride / dichloromethane; diethyl ether / 2 h / 20 °C

With hydrogenchloride; dmap; triethylamine; HATU; trifluoroacetic acid; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;