ethyl 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-8-methyl-3-azaspiro[5.5]undecan-9-yl)acetate

Base Information

Chemical Name:ethyl 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-8-methyl-3-azaspiro[5.5]undecan-9-yl)acetate
CAS No.:1599479-13-6
Molecular Formula:C₂₂H₂₉ClF₃NO₃
Molecular Weight:447.925
Hs Code.:

Synonyms:ethyl 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-8-methyl-3-azaspiro[5.5]undecan-9-yl)acetate

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Chemical Property of ethyl 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-8-methyl-3-azaspiro[5.5]undecan-9-yl)acetate

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Technology Process of ethyl 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-8-methyl-3-azaspiro[5.5]undecan-9-yl)acetate

There total 4 articles about ethyl 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-8-methyl-3-azaspiro[5.5]undecan-9-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 468075-00-5
1-bromo-2-chloro-4-(trifluoromethoxy)benzene

: 1599479-12-5
ethyl 2-(8-methyl-3-azaspiro[5.5]undecan-9-yl)acetate

: 1599479-13-6
ethyl 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-8-methyl-3-azaspiro[5.5]undecan-9-yl)acetate

Guidance literature:: With chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); caesium carbonate; In 1,4-dioxane; at 100 ℃; Microwave irradiation; Inert atmosphere; Sealed tube;

Reference yield:

: 1599479-09-0
benzyl 8-methyl-9-oxo-3-azaspiro[5.5]undecane-3-carboxylate

: 1599479-13-6
ethyl 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-8-methyl-3-azaspiro[5.5]undecan-9-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 20 °C

2.1: 20% palladium hydroxide-activated charcoal; hydrogen / ethyl acetate

3.1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); caesium carbonate / 1,4-dioxane / 100 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;

Reference yield:

: 1056629-20-9
3-azaspiro[5.5]undecane-3-carboxylic acid, 9-oxo, phenylmethyl ester

: 1599479-13-6
ethyl 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-8-methyl-3-azaspiro[5.5]undecan-9-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: 2.5 h / -78 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

3.1: 20% palladium hydroxide-activated charcoal; hydrogen / ethyl acetate

4.1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); caesium carbonate / 1,4-dioxane / 100 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;