2-(tert-butyl)-5-((4-methoxybenzyl)thio)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazole

Base Information

Chemical Name:2-(tert-butyl)-5-((4-methoxybenzyl)thio)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazole
CAS No.:1001076-49-8
Molecular Formula:C₂₅H₃₂N₂O₂S
Molecular Weight:424.607
Hs Code.:

Synonyms:2-(tert-butyl)-5-((4-methoxybenzyl)thio)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazole

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Chemical Property of 2-(tert-butyl)-5-((4-methoxybenzyl)thio)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazole

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Technology Process of 2-(tert-butyl)-5-((4-methoxybenzyl)thio)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazole

There total 12 articles about 2-(tert-butyl)-5-((4-methoxybenzyl)thio)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1001076-48-7
C₂₅H₃₄N₂O₃S

: 1001076-49-8
2-(tert-butyl)-5-((4-methoxybenzyl)thio)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazole

Guidance literature:: With acetic acid; at 6 ℃; Heating;
DOI:10.1016/j.bmcl.2008.03.048

Reference yield: 44.0%

: 886049-87-2
5-bromo-2-(tert-butyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazole

: 6258-60-2
p-methoxybenzylmercaptan

: 1001076-49-8
2-(tert-butyl)-5-((4-methoxybenzyl)thio)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazole

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 18h; Inert atmosphere;
DOI:10.1039/c9ob00656g

Reference yield:

: 3460-18-2
1,4-dibromo-2-nitrobenzene

: 1001076-49-8
2-(tert-butyl)-5-((4-methoxybenzyl)thio)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 48 h / 100 °C / Sealed tube; Inert atmosphere

2: ammonium chloride; iron / ethanol; water / 2 h / 40 °C / Inert atmosphere

3: pyridine; dmap / dichloromethane / 20 °C / Inert atmosphere; Reflux

4: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 130 °C / Sealed tube; Inert atmosphere

5: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

With pyridine; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; ammonium chloride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c9ob00656g