3',5'-di-O-benzyl-4'-C-(p-toluenesulfonyloxyethyl)-2'-O-acetyl-4-N-benzoylcytidine

Base Information

• Chemical Name: 3',5'-di-O-benzyl-4'-C-(p-toluenesulfonyloxyethyl)-2'-O-acetyl-4-N-benzoylcytidine
• CAS No.: 287737-67-1
• Molecular Formula: C₄₁H₄₁N₃O₁₀S
• Molecular Weight: 767.857
• Mol file: 287737-67-1.mol

Synonyms:3',5'-di-O-benzyl-4'-C-(p-toluenesulfonyloxyethyl)-2'-O-acetyl-4-N-benzoylcytidine

Chemical Property of 3',5'-di-O-benzyl-4'-C-(p-toluenesulfonyloxyethyl)-2'-O-acetyl-4-N-benzoylcytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3',5'-di-O-benzyl-4'-C-(p-toluenesulfonyloxyethyl)-2'-O-acetyl-4-N-benzoylcytidine

There total 2 articles about 3',5'-di-O-benzyl-4'-C-(p-toluenesulfonyloxyethyl)-2'-O-acetyl-4-N-benzoylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-(2-((1-trimethylsilyl)oxy)pyrimidin-4-yl)benzamide (238096-55-4) + (3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-5-(2-(tosyloxy)ethyl)tetrahydrofuran-2,3-diyl diacetate (452949-21-2) → 3',5'-di-O-benzyl-4'-C-(p-toluenesulfonyloxyethyl)-2'-O-acetyl-4-N-benzoylcytidine (287737-67-1)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 50 ℃; for 1h;

DOI:10.1016/S0968-0896(03)00115-9

Reference yield: 83.0%

→ 3',5'-di-O-benzyl-4'-C-(p-toluenesulfonyloxyethyl)-2'-O-acetyl-4-N-benzoylcytidine (287737-67-1)

Guidance literature:

Reference yield: 68.0%

3',5'-di-O-benzyl-4'-C-(p-toluenesulfonyloxyethyl)-2'-O-acetyl-4-N-benzoylcytidine (287737-67-1) → 3',5'-di-O-benzyl-2'-O,4'-C-ethylene-4-N-benzoylcytidine (287737-32-0)

Guidance literature:

With pyridine; sodium hydroxide; at 20 ℃; for 1h;

DOI:10.1016/S0968-0896(03)00115-9

upstream raw materials:

N-(2-((1-trimethylsilyl)oxy)pyrimidin-4-yl)benzamide

(3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-5-(2-(tosyloxy)ethyl)tetrahydrofuran-2,3-diyl diacetate

Downstream raw materials:

3',5'-di-O-benzyl-2'-O,4'-C-ethylene-4-N-benzoylcytidine