N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-trypthophane benzyl ester

Base Information

• Chemical Name: N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-trypthophane benzyl ester
• CAS No.: 1185198-44-0
• Molecular Formula: C₃₃H₃₄ClN₇O₄
• Molecular Weight: 628.13

Synonyms:N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-trypthophane benzyl ester

Chemical Property of N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-trypthophane benzyl ester

Chemical Property:

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Technology Process of N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-trypthophane benzyl ester

There total 2 articles about N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-trypthophane benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine (1185198-27-9) + L-tryptophan benzyl ester p-toluenesulfonic acid salt (4289-01-4,53787-20-5) → N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-trypthophane benzyl ester (1185198-44-0)

Guidance literature:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

L-tryptophan benzyl ester p-toluenesulfonic acid salt; With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃; for 0.333333h; pH=9;

In tetrahydrofuran; at 0 - 20 ℃; for 50h;

DOI:10.1016/j.bmc.2009.07.035

Reference yield:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine (1185198-27-9) + L-tryptophane benzyl ester (4299-69-8,141595-98-4) → N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-trypthophane benzyl ester (1185198-44-0)

Guidance literature:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

L-tryptophane benzyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 50h;

DOI:10.1016/j.bmcl.2009.05.077

Reference yield: 90.0%

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-trypthophane benzyl ester (1185198-44-0) → N-(2-chloro-9H-purin-6-yl)-N-cyclopropylglycyl-L-tryptophan benzyl ester (1185198-64-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmc.2009.07.035

upstream raw materials:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine

L-tryptophane benzyl ester

L-tryptophan benzyl ester p-toluenesulfonic acid salt

Downstream raw materials:

N-(2-chloro-9H-purin-6-yl)-N-cyclopropylglycyl-L-tryptophan benzyl ester

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