2-Oxo-2H-chromene-3-carboxylic acid [1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Base Information

• Chemical Name: 2-Oxo-2H-chromene-3-carboxylic acid [1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide
• CAS No.: 143814-49-7
• Molecular Formula: C₁₉H₁₆N₂O₅
• Molecular Weight: 352.346
• Mol file: 143814-49-7.mol

Synonyms:2-Oxo-2H-chromene-3-carboxylic acid [1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Chemical Property of 2-Oxo-2H-chromene-3-carboxylic acid [1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Oxo-2H-chromene-3-carboxylic acid [1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide

There total 4 articles about 2-Oxo-2H-chromene-3-carboxylic acid [1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-oxo-2H-chromene-3-carbohydrazide (1846-91-9) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 2-Oxo-2H-chromene-3-carboxylic acid [1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide (143814-49-7)

Guidance literature:

With hydrogenchloride; In ethanol; Reflux;

DOI:10.2174/1573406416666200121105215

Reference yield:

ethyl coumarin-3-carboxylate (1846-76-0) → 2-Oxo-2H-chromene-3-carboxylic acid [1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide (143814-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / hydrazine hydrate / ethanol / Heating

2: 65 percent / acetic acid / ethanol / 5 h / Heating

With hydrazine hydrate; acetic acid; In ethanol;

Reference yield:

salicylaldehyde (90-02-8) → 2-Oxo-2H-chromene-3-carboxylic acid [1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide (143814-49-7)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / 42 h / 120 °C

2: hydrazine / ethanol / 2 h / Reflux

3: ethanol / Reflux

With piperidine; hydrazine; In ethanol; 1: Knoevenagel condensation;

DOI:10.1111/j.1747-0285.2011.01120.x

upstream raw materials:

2-oxo-2H-chromene-3-carbohydrazide

3,4-dimethoxy-benzaldehyde

ethyl coumarin-3-carboxylate

salicylaldehyde

Downstream raw materials:

2-Oxo-2H-chromene-3-carboxylic acid [1-(3,4-dimethoxy-phenyl)-1-m-tolylazo-meth-(Z)-ylidene]-hydrazide

2-Oxo-2H-chromene-3-carboxylic acid [1-(3-chloro-phenylazo)-1-(3,4-dimethoxy-phenyl)-meth-(Z)-ylidene]-hydrazide

3-(5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)-2H-chromen-2-one

2-Oxo-2H-chromene-3-carboxylic acid [1-(4-chloro-phenylazo)-1-(3,4-dimethoxy-phenyl)-meth-(Z)-ylidene]-hydrazide