3-(4-[5-[(2R,6S)-2,6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-N-hydroxytrifluoroacetobenzenecarboximidamide

Base Information

Chemical Name:3-(4-[5-[(2R,6S)-2,6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-N-hydroxytrifluoroacetobenzenecarboximidamide
CAS No.:244621-34-9
Molecular Formula:C₂₉H₃₅F₃N₄O₄
Molecular Weight:560.617
Hs Code.:

3-(4-[5-[(2R,6S)-2,6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-N-hydroxytrifluoroacetobenzenecarboximidamide

Synonyms:3-(4-[5-[(2R,6S)-2,6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-N-hydroxytrifluoroacetobenzenecarboximidamide

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Chemical Property of 3-(4-[5-[(2R,6S)-2,6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-N-hydroxytrifluoroacetobenzenecarboximidamide

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Technology Process of 3-(4-[5-[(2R,6S)-2,6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-N-hydroxytrifluoroacetobenzenecarboximidamide

There total 7 articles about 3-(4-[5-[(2R,6S)-2,6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-N-hydroxytrifluoroacetobenzenecarboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 407-25-0
trifluoroacetic anhydride

: 244618-40-4
3-(4-[5-[(2R,6S)-2,6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-N-hydroxybenzenecarboximidamide

: 244621-34-9
3-(4-[5-[(2R,6S)-2,6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-N-hydroxytrifluoroacetobenzenecarboximidamide

Guidance literature:: at 20 ℃; for 2h;
DOI:10.1021/jm000074l

Reference yield:

: bromo-(3-bromo-phenyl)-acetyl bromide

: 244621-34-9
3-(4-[5-[(2R,6S)-2,6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-N-hydroxytrifluoroacetobenzenecarboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 55 percent / NaH / dimethylformamide / 24 h / 20 °C

2.1: 76 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dimethylformamide / 5 h / 100 °C

3.1: NaH / dimethylformamide / 0.25 h / 70 °C

3.2: 56 percent / dimethylformamide / 3 h / 70 °C

4.1: 94 percent / 16 h / 70 °C

5.1: hydroxylamine hydrochloride; DIEA / methanol / 16 h / 20 °C

6.1: 100 percent / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; 1.1: Acylation / 2.1: cyclocondensation / 3.1: Substitution / 4.1: deprotonation / 4.2: Alkylation / 5.1: Alkylation / 6.1: Addition / 7.1: Acylation;
DOI:10.1021/jm000074l

Reference yield:

: 163339-67-1
methyl 2-bromo-2-(3-bromophenyl)acetate

: 244621-34-9
3-(4-[5-[(2R,6S)-2,6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-N-hydroxytrifluoroacetobenzenecarboximidamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 55 percent / NaH / dimethylformamide / 24 h / 20 °C

2.1: 76 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dimethylformamide / 5 h / 100 °C

3.1: NaH / dimethylformamide / 0.25 h / 70 °C

3.2: 56 percent / dimethylformamide / 3 h / 70 °C

4.1: 94 percent / 16 h / 70 °C

5.1: hydroxylamine hydrochloride; DIEA / methanol / 16 h / 20 °C

6.1: 100 percent / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; 1.1: cyclocondensation / 2.1: Substitution / 3.1: deprotonation / 3.2: Alkylation / 4.1: Alkylation / 5.1: Addition / 6.1: Acylation;
DOI:10.1021/jm000074l