(1R,6R)-ethyl 1'-benzoyl-4-phenyl-2,2'-dioxospiro[cyclohex[3]ene-1,3'-indoline]-6-carboxylate

Base Information

Chemical Name:(1R,6R)-ethyl 1'-benzoyl-4-phenyl-2,2'-dioxospiro[cyclohex[3]ene-1,3'-indoline]-6-carboxylate
CAS No.:1447519-56-3
Molecular Formula:C₂₉H₂₃NO₅
Molecular Weight:465.505
Hs Code.:

Synonyms:(1R,6R)-ethyl 1'-benzoyl-4-phenyl-2,2'-dioxospiro[cyclohex[3]ene-1,3'-indoline]-6-carboxylate

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Chemical Property of (1R,6R)-ethyl 1'-benzoyl-4-phenyl-2,2'-dioxospiro[cyclohex[3]ene-1,3'-indoline]-6-carboxylate

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Technology Process of (1R,6R)-ethyl 1'-benzoyl-4-phenyl-2,2'-dioxospiro[cyclohex[3]ene-1,3'-indoline]-6-carboxylate

There total 3 articles about (1R,6R)-ethyl 1'-benzoyl-4-phenyl-2,2'-dioxospiro[cyclohex[3]ene-1,3'-indoline]-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: C₁₉H₁₅NO₄

: 68204-17-1
3-phenylbut-2-enoyl chloride

: 1447519-56-3
(1R,6R)-ethyl 1'-benzoyl-4-phenyl-2,2'-dioxospiro[cyclohex[3]ene-1,3'-indoline]-6-carboxylate

Guidance literature:: With 2-((1S)-(6-methoxyquinolin-4-yl)((trimethylsilyl)oxy)methyl)5-vinylquinuclidine; triethylamine; In tetrahydrofuran; at -78 ℃; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1002/anie.201207405

Reference yield:

: 1248518-60-6
(E)-ethyl 2-(1-benzoyl-2-oxoindolin-3-ylidene)acetate

: 38425-47-7
3-phenyl-2-cyclobuten-1-one

: 1447519-56-3
(1R,6R)-ethyl 1'-benzoyl-4-phenyl-2,2'-dioxospiro[cyclohex[3]ene-1,3'-indoline]-6-carboxylate

: C₂₉H₂₃NO₅

: ethyl 1'-benzoyl-4-phenyl-2,2'-dioxospiro[cyclohexane-1,3'-indolin]-3-ene-6-carboxylate

Guidance literature:: With C₄₃H₆₄N₄O₄; dysprosium(III) trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 60 ℃; for 16h; Reagent/catalyst; Overall yield = 32 percent; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1021/acs.orglett.0c00608

Reference yield:

: 1248518-60-6
(E)-ethyl 2-(1-benzoyl-2-oxoindolin-3-ylidene)acetate

: 38425-47-7
3-phenyl-2-cyclobuten-1-one

: 1447519-56-3
(1R,6R)-ethyl 1'-benzoyl-4-phenyl-2,2'-dioxospiro[cyclohex[3]ene-1,3'-indoline]-6-carboxylate

: ethyl 1'-benzoyl-4-phenyl-2,2'-dioxospiro[cyclohexane-1,3'-indolin]-3-ene-6-carboxylate

Guidance literature:: With C₃₅H₄₈N₄O₄; dysprosium(III) trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 50 ℃; for 48h; Reagent/catalyst; Solvent; Temperature; Overall yield = 64 percent; Overall yield = 29.8 mg; enantioselective reaction; Catalytic behavior; Inert atmosphere; Molecular sieve;
DOI:10.1021/acs.orglett.0c00608