5-(tert-butylimino)-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

Base Information

Chemical Name:5-(tert-butylimino)-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one
CAS No.:1452386-69-4
Molecular Formula:C₂₅H₂₄N₄O
Molecular Weight:396.492
Hs Code.:

Synonyms:5-(tert-butylimino)-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

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Chemical Property of 5-(tert-butylimino)-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

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Technology Process of 5-(tert-butylimino)-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

There total 10 articles about 5-(tert-butylimino)-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 1452386-60-5
2-(2-bromophenyl)-3-(phenylamino)-1-(prop-2-ynyl)-2,3-dihydroquinazolin-4(1H)-one

: 1452386-69-4
5-(tert-butylimino)-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

: 1452386-74-1
5-(tert-butylimino)-6-phenyl-5,6-dihydro-8H-phthalazino[1,2-b]quinazolin-8-one

Guidance literature:: With palladium diacetate; caesium carbonate; In toluene; at 110 ℃; for 24h; Mechanism; Sealed tube;
DOI:10.1055/s-0033-1338936

Reference yield: 65.0%

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 1375103-52-8
2-(2-bromophenyl)-3-(phenylamino)-2,3-dihydroquinazol-in-4(H)-one

: 1452386-69-4
5-(tert-butylimino)-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

Guidance literature:: With palladium diacetate; caesium carbonate; In toluene; at 110 ℃; for 24h; Sealed tube;
DOI:10.1055/s-0033-1338936

Reference yield:

: 50784-22-0
N¹-(prop-2-yn-1-yl)isatoic anhydride

: 1452386-69-4
5-(tert-butylimino)-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / Reflux

1.2: 81 °C

2.1: palladium diacetate / toluene / 24 h / 110 °C / Sealed tube

3.1: palladium diacetate; caesium carbonate / toluene / 24 h / 110 °C / Sealed tube

With palladium diacetate; caesium carbonate; In toluene; acetonitrile;
DOI:10.1055/s-0033-1338936