6-(4-[3-(2,6-dichloro-phenyl)-5-trifluoromethyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl)-benzo[b]thiophene-3-carboxylic acid methylester

Base Information

Chemical Name:6-(4-[3-(2,6-dichloro-phenyl)-5-trifluoromethyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl)-benzo[b]thiophene-3-carboxylic acid methylester
CAS No.:959801-09-3
Molecular Formula:C₂₇H₁₈Cl₂F₃N₃O₃S
Molecular Weight:592.425
Hs Code.:

Synonyms:6-(4-[3-(2,6-dichloro-phenyl)-5-trifluoromethyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl)-benzo[b]thiophene-3-carboxylic acid methylester

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Chemical Property of 6-(4-[3-(2,6-dichloro-phenyl)-5-trifluoromethyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl)-benzo[b]thiophene-3-carboxylic acid methylester

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Technology Process of 6-(4-[3-(2,6-dichloro-phenyl)-5-trifluoromethyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl)-benzo[b]thiophene-3-carboxylic acid methylester

There total 4 articles about 6-(4-[3-(2,6-dichloro-phenyl)-5-trifluoromethyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl)-benzo[b]thiophene-3-carboxylic acid methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 946427-38-9
6-(4-hydroxy-2-methyl-phenyl)-benzo[b]thiophene-3-carboxylic acid methyl ester

: 959800-67-0
[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-yl]-methanol

: 959801-09-3
6-(4-[3-(2,6-dichloro-phenyl)-5-trifluoromethyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl)-benzo[b]thiophene-3-carboxylic acid methylester

Guidance literature:: With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; at 20 ℃; for 18h;

Reference yield:

: 959800-65-8
3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazole-4-carboxylic acid ethyl ester

: 959801-09-3
6-(4-[3-(2,6-dichloro-phenyl)-5-trifluoromethyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl)-benzo[b]thiophene-3-carboxylic acid methylester

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0 - 20 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 18 h / 20 °C

With tributylphosphine; diisobutylaluminium hydride; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; toluene; 2: Mitsunobu reaction;

Reference yield:

: 57341-09-0
1-azido-2,6-dichlorobenzene

: 959801-09-3
6-(4-[3-(2,6-dichloro-phenyl)-5-trifluoromethyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl)-benzo[b]thiophene-3-carboxylic acid methylester

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 120 °C

2: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0 - 20 °C

3: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 18 h / 20 °C

With tributylphosphine; diisobutylaluminium hydride; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; toluene; 3: Mitsunobu reaction;