4-Thiazolecarboxylic acid, 5-ethyl-

Base Information

• Chemical Name: 4-Thiazolecarboxylic acid, 5-ethyl-
• CAS No.: 864437-40-1
• Molecular Formula: C₆H₇NO₂S
• Molecular Weight: 157.193
• Hs Code.: 2934100090
• Mol file: 864437-40-1.mol

Synonyms:4-Thiazolecarboxylic acid, 5-ethyl-

Chemical Property of 4-Thiazolecarboxylic acid, 5-ethyl-

Chemical Property:

• PSA: 78.43000
• LogP: 1.40370

Purity/Quality:

5-Ethylthiazole-4-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Thiazolecarboxylic acid, 5-ethyl-

There total 2 articles about 4-Thiazolecarboxylic acid, 5-ethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

methyl 5-ethylthiazole-4-carboxylate (81569-45-1) → 5-ethyl-1,3-thiazole-4-carboxylic acid (864437-40-1)

Guidance literature:

methyl 5-ethylthiazole-4-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

With hydrogenchloride; In diethyl ether;

Reference yield:

methyl 2-amino-5-ethyl-1,3-thiazole-4-carboxylate (28942-54-3) → 5-ethyl-1,3-thiazole-4-carboxylic acid (864437-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaNO₂; H₃PO₂

2: aq. LiOH / methanol

With lithium hydroxide; hypophosphorous acid; sodium nitrite; In methanol;

DOI:10.1016/j.bmcl.2005.05.055

upstream raw materials:

methyl 5-ethylthiazole-4-carboxylate

methyl 2-amino-5-ethyl-1,3-thiazole-4-carboxylate

Refernces

• 1、 -. "HEPATITIS C VIRUS INHIBITORS". Page/Page column 127. . Retrieved 2012/02/15.
• 2、 -. "HEPATITIS C VIRUS INHIBITORS". Page/Page column 123. . Retrieved 2011/07/07.