(1RS,2RS)-3-(t-butyldiphenylsiloxy)-2-methyl-1-<1-(phenylthio)cyclopentyl>propan-1-ol

Base Information

Chemical Name:(1RS,2RS)-3-(t-butyldiphenylsiloxy)-2-methyl-1-<1-(phenylthio)cyclopentyl>propan-1-ol
CAS No.:133030-63-4
Molecular Formula:C₃₁H₄₀O₂SSi
Molecular Weight:504.809
Hs Code.:

Synonyms:(1RS,2RS)-3-(t-butyldiphenylsiloxy)-2-methyl-1-<1-(phenylthio)cyclopentyl>propan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1RS,2RS)-3-(t-butyldiphenylsiloxy)-2-methyl-1-<1-(phenylthio)cyclopentyl>propan-1-ol

Chemical Property:

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Technology Process of (1RS,2RS)-3-(t-butyldiphenylsiloxy)-2-methyl-1-<1-(phenylthio)cyclopentyl>propan-1-ol

There total 3 articles about (1RS,2RS)-3-(t-butyldiphenylsiloxy)-2-methyl-1-<1-(phenylthio)cyclopentyl>propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 120749-37-3,133030-55-4,138751-07-2
(1RS,2RS)-2-methyl-1-<1-(phenylthio)cyclopentyl>propane-1,3-diol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 133030-63-4
(1RS,2RS)-3-(t-butyldiphenylsiloxy)-2-methyl-1-<1-(phenylthio)cyclopentyl>propan-1-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

Reference yield:

: 115205-40-8
1-phenylsulfanylcyclopentane carboxaldehyde

: 133030-63-4
(1RS,2RS)-3-(t-butyldiphenylsiloxy)-2-methyl-1-<1-(phenylthio)cyclopentyl>propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, -78 degC, 10 min 2.) -78 degC, 5 min

2: 85 percent / LiAlH₄ / diethyl ether / 4 h / 0 °C

3: 83 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; lithium diisopropyl amide; In diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 133030-44-1
(2RS,3SR)-2,6-dimethylphenyl 3-hydroxy-2-methyl-3-<1-(phenylthio)cyclopentyl>propionate

: 133030-63-4
(1RS,2RS)-3-(t-butyldiphenylsiloxy)-2-methyl-1-<1-(phenylthio)cyclopentyl>propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / LiAlH₄ / diethyl ether / 4 h / 0 °C

2: 83 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; In diethyl ether; N,N-dimethyl-formamide;