N-((S)-2-hydroxy-1-phenyl-1-((R)-2,4,4-trimethyltetrahydrofuran-2-yl)ethyl)-3,4,5-trimethoxybenzamide

Base Information

Chemical Name:N-((S)-2-hydroxy-1-phenyl-1-((R)-2,4,4-trimethyltetrahydrofuran-2-yl)ethyl)-3,4,5-trimethoxybenzamide
CAS No.:1344031-78-2
Molecular Formula:C₂₅H₃₃NO₆
Molecular Weight:443.54
Hs Code.:

Synonyms:N-((S)-2-hydroxy-1-phenyl-1-((R)-2,4,4-trimethyltetrahydrofuran-2-yl)ethyl)-3,4,5-trimethoxybenzamide

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Chemical Property of N-((S)-2-hydroxy-1-phenyl-1-((R)-2,4,4-trimethyltetrahydrofuran-2-yl)ethyl)-3,4,5-trimethoxybenzamide

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Technology Process of N-((S)-2-hydroxy-1-phenyl-1-((R)-2,4,4-trimethyltetrahydrofuran-2-yl)ethyl)-3,4,5-trimethoxybenzamide

There total 3 articles about N-((S)-2-hydroxy-1-phenyl-1-((R)-2,4,4-trimethyltetrahydrofuran-2-yl)ethyl)-3,4,5-trimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1344031-36-2
(R)-4-phenyl-2-(3,4,5-trimethoxyphenyl)-4-((R)-2,4,4-trimethyltetrahydrofuran-2-yl)oxazol-5(4H)-one

: 1344031-78-2
N-((S)-2-hydroxy-1-phenyl-1-((R)-2,4,4-trimethyltetrahydrofuran-2-yl)ethyl)-3,4,5-trimethoxybenzamide

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether;
DOI:10.1016/j.tetlet.2011.08.123

Reference yield:

: 1344031-31-7
4-phenyl-2-(3,4,5-trimethoxyphenyl)oxazol-5(4H)-one

: 1344031-78-2
N-((S)-2-hydroxy-1-phenyl-1-((R)-2,4,4-trimethyltetrahydrofuran-2-yl)ethyl)-3,4,5-trimethoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: C₃₀H₄₈AuP; (S)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate / toluene / 48 h / 0 °C / Molecular sieve; Inert atmosphere

2: lithium aluminium tetrahydride / diethyl ether

With lithium aluminium tetrahydride; C₃₀H₄₈AuP; (S)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate; In diethyl ether; toluene;
DOI:10.1016/j.tetlet.2011.08.123

Reference yield:

: 107540-03-4
2,2-dimethylpent-4-yn-1-ol

: 1344031-78-2
N-((S)-2-hydroxy-1-phenyl-1-((R)-2,4,4-trimethyltetrahydrofuran-2-yl)ethyl)-3,4,5-trimethoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: Au(CH₃)(tBuXPhos); (S)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate / toluene / 48 h / 0 °C / Molecular sieve; Inert atmosphere

2: lithium aluminium tetrahydride / diethyl ether

With lithium aluminium tetrahydride; Au(CH₃)(tBuXPhos); (S)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate; In diethyl ether; toluene;
DOI:10.1016/j.tetlet.2011.08.123