1-chloro-2-[(3-chloro-4-methoxyphenyl)dimethylsilyl]ethane

Base Information

• Chemical Name: 1-chloro-2-[(3-chloro-4-methoxyphenyl)dimethylsilyl]ethane
• CAS No.: 152879-07-7
• Molecular Formula: C₁₁H₁₆Cl₂OSi
• Molecular Weight: 263.239
• Mol file: 152879-07-7.mol

Synonyms:1-chloro-2-[(3-chloro-4-methoxyphenyl)dimethylsilyl]ethane

Chemical Property of 1-chloro-2-[(3-chloro-4-methoxyphenyl)dimethylsilyl]ethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-chloro-2-[(3-chloro-4-methoxyphenyl)dimethylsilyl]ethane

There total 3 articles about 1-chloro-2-[(3-chloro-4-methoxyphenyl)dimethylsilyl]ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(3-chloro-4-methoxyphenyl)dimethylsilyl]ethanol (872210-42-9) → 1-chloro-2-[(3-chloro-4-methoxyphenyl)dimethylsilyl]ethane (152879-07-7)

Guidance literature:

With thionyl chloride; In diethyl ether; at 0 ℃;

DOI:10.1246/bcsj.78.1834

Reference yield:

(3-chloro-4-methoxy-phenyl)-chloromethyl-dimethyl-silane → 1-chloro-2-[(3-chloro-4-methoxyphenyl)dimethylsilyl]ethane (152879-07-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Mg / diethyl ether

1.2: diethyl ether

2.1: LiAlH₄ / diethyl ether / Heating

3.1: SOCl₂ / diethyl ether / 0 °C

With lithium aluminium tetrahydride; thionyl chloride; magnesium; In diethyl ether;

DOI:10.1246/bcsj.78.1834

Reference yield:

ethyl [(3-chloro-4-methoxyphenyl)dimethylsilyl]acetate (872210-39-4) → 1-chloro-2-[(3-chloro-4-methoxyphenyl)dimethylsilyl]ethane (152879-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / Heating

2: SOCl₂ / diethyl ether / 0 °C

With lithium aluminium tetrahydride; thionyl chloride; In diethyl ether;

DOI:10.1246/bcsj.78.1834

upstream raw materials:

2-[(3-chloro-4-methoxyphenyl)dimethylsilyl]ethanol

ethyl [(3-chloro-4-methoxyphenyl)dimethylsilyl]acetate

Downstream raw materials:

2-[(3-chloro-4-methoxyphenyl)dimethylsilyl]ethanol

ethene