tert-butyl (2S,5S)-2-(tert-butyl)-3-methyl-4-oxo-5-(2-thenyl)-1-imidazolidinecarboxylate

Base Information

• Chemical Name: tert-butyl (2S,5S)-2-(tert-butyl)-3-methyl-4-oxo-5-(2-thenyl)-1-imidazolidinecarboxylate
• CAS No.: 123052-84-6
• Molecular Formula: C₁₈H₂₈N₂O₃S
• Molecular Weight: 352.498
• Mol file: 123052-84-6.mol

Synonyms:tert-butyl (2S,5S)-2-(tert-butyl)-3-methyl-4-oxo-5-(2-thenyl)-1-imidazolidinecarboxylate

Chemical Property of tert-butyl (2S,5S)-2-(tert-butyl)-3-methyl-4-oxo-5-(2-thenyl)-1-imidazolidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl (2S,5S)-2-(tert-butyl)-3-methyl-4-oxo-5-(2-thenyl)-1-imidazolidinecarboxylate

There total 1 articles about tert-butyl (2S,5S)-2-(tert-butyl)-3-methyl-4-oxo-5-(2-thenyl)-1-imidazolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-thenyl bromide (45438-73-1) + (2S)-1-(tert-butyloxycarbonyl)-2-tert-butyl-3-methylimidazolidin-4-one (119838-38-9) → tert-butyl (2S,5S)-2-(tert-butyl)-3-methyl-4-oxo-5-(2-thenyl)-1-imidazolidinecarboxylate (123052-84-6)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, 40 min: 2.) THF, hexane, -78 deg C;

Reference yield:

tert-butyl (2S,5S)-2-(tert-butyl)-3-methyl-4-oxo-5-(2-thenyl)-1-imidazolidinecarboxylate (123052-84-6) → L-3-(2-thienyl)alanine (22951-96-8,139-86-6)

Guidance literature:

With hydrogenchloride; Dowex 50-WX₈; acetic acid; trifluoroacetic acid; Yield given. Multistep reaction; 1.) CH₂Cl₂, 30 min, 0 deg C; 12 h, room temperature; 2.) 100-105 deg C, toluene, water, 36 h;

upstream raw materials:

2-thenyl bromide

(2S)-1-(tert-butyloxycarbonyl)-2-tert-butyl-3-methylimidazolidin-4-one

Downstream raw materials:

L-3-(2-thienyl)alanine