4,4a,5,6,7,8-hexahydro-5β-methoxy-4aβ-methyl-8α-(thiophenoxy)methyl-2(3H)-naphthalenone

Base Information

Chemical Name:4,4a,5,6,7,8-hexahydro-5β-methoxy-4aβ-methyl-8α-(thiophenoxy)methyl-2(3H)-naphthalenone
CAS No.:127897-04-5
Molecular Formula:C₁₉H₂₄O₂S
Molecular Weight:316.464
Hs Code.:

Synonyms:4,4a,5,6,7,8-hexahydro-5β-methoxy-4aβ-methyl-8α-(thiophenoxy)methyl-2(3H)-naphthalenone

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Chemical Property of 4,4a,5,6,7,8-hexahydro-5β-methoxy-4aβ-methyl-8α-(thiophenoxy)methyl-2(3H)-naphthalenone

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Technology Process of 4,4a,5,6,7,8-hexahydro-5β-methoxy-4aβ-methyl-8α-(thiophenoxy)methyl-2(3H)-naphthalenone

There total 6 articles about 4,4a,5,6,7,8-hexahydro-5β-methoxy-4aβ-methyl-8α-(thiophenoxy)methyl-2(3H)-naphthalenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 125488-97-3
4,4a,5,6,7,8-hexahydro-5β-methoxy-4aβ-methyl-8-methylene-2(3H)-naphthalenone

: 108-98-5
thiophenol

: 127897-04-5
4,4a,5,6,7,8-hexahydro-5β-methoxy-4aβ-methyl-8α-(thiophenoxy)methyl-2(3H)-naphthalenone

Guidance literature:: With potassium carbonate;
DOI:10.1016/S0040-4039(01)93835-3

Reference yield:

: 34996-06-0
(4αR,5R)-5-hydroxy-4α-methyl-4,4α,5,6,7,8-hexahydronaphthalen-2(3H)-one

: 127897-04-5
4,4a,5,6,7,8-hexahydro-5β-methoxy-4aβ-methyl-8α-(thiophenoxy)methyl-2(3H)-naphthalenone

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / sodium hydride / dimethylformamide / 0.5 h / -20 °C

2: 94 percent / NEt₃ / dimethylformamide / 18 h / 110 °C

3: 85 percent / CH₂Cl₂ / 19 h / 25 °C

4: 16 g / diethyl ether / 2 h / Heating

5: 73 percent / 20percent NaOH / ethyl acetate / 3 h / 25 °C

6: 85 percent / K₂CO₃ / ethanol / 4 h / 0 °C

With sodium hydroxide; sodium hydride; potassium carbonate; triethylamine; In diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 125488-83-7
4,4a,5,6,7,8-hexahydro-5β-methoxy-4aβ-methyl-2(3H)-naphthalenone

: 127897-04-5
4,4a,5,6,7,8-hexahydro-5β-methoxy-4aβ-methyl-8α-(thiophenoxy)methyl-2(3H)-naphthalenone

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / NEt₃ / dimethylformamide / 18 h / 110 °C

2: 85 percent / CH₂Cl₂ / 19 h / 25 °C

3: 16 g / diethyl ether / 2 h / Heating

4: 73 percent / 20percent NaOH / ethyl acetate / 3 h / 25 °C

5: 85 percent / K₂CO₃ / ethanol / 4 h / 0 °C

With sodium hydroxide; potassium carbonate; triethylamine; In diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;